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Fintech

Soligenix, Inc. COVID-19 Vaccine Candidate, CiVax, Could Be a More Viable Alternative to Moderna and Pfizer

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New York, New York–(Newsfile Corp. – December 9, 2020) –  The COVID-19 pandemic has been one of the most significant “black swan” events in recent history. As of early December 2020, around 1.5 million people globally have died from the coronavirus, including over 274,000 deaths in the United States. At the same time, millions of people have lost their jobs, businesses, and other income sources. The only way to truly recover from this pandemic is from widespread vaccination and continued adherence to social distancing, hand-washing, and other preventative measures.

Pfizer and Moderna are two of the most hyped companies that are developing coronavirus vaccines. Both vaccines are said to show effectiveness greater than 90% in protecting the individual from severe coronavirus symptoms.

However, with both the Pfizer and Moderna vaccines, there remain numerous safety and efficacy questions, as well as the looming logistical nightmare of storage. Soligenix, Inc. (NASDAQ: SNGX) is one company that is developing a coronavirus vaccine candidate that may have the answer to several of these issues.

Questions Surround Moderna & Pfizer Vaccines

Moderna and Pfizer are just a couple of biotechnology companies that are developing vaccines to help combat the pandemic. Their efforts and ability to churn out a viable vaccine in record time is extremely meaningful and an important milestone in medicine.

New Vaccine Technology

However, both companies are utilizing a new vaccine technology, which has not undergone long-term safety and efficacy testing. There has never been a vaccine approved using mRNA technology.

Using synthetic mRNA technology, the Moderna and Pfizer vaccines seek to activate an immune response against the coronavirus. Early clinical study data show that both vaccines have effectiveness above 90%. The important factor to understand is that these vaccines have effectiveness in preventing the vaccinated individual from experiencing severe COVID infection. However, it may not protect against that same vaccinated individual from still carrying and transmitting the virus to others. To make matters worse, those receiving mRNA-based vaccines will need two shots several weeks apart.

mRNA Vaccine Storage Logistical Nightmare

Another issue with these mRNA vaccines is that they must be kept at -94 degrees Fahrenheit or below and they do not have a long shelf-life once it is removed from its freezer storage. According to Time Magazine, the Pfizer vaccine can only last for roughly five days once they are removed from cold storage and placed into a standard refrigerator.

Even the most prestigious hospitals and healthcare organizations, such as the Mayo Clinic, do not currently have the storage ability to keep these vaccines at such a cold temperature. If the Mayo Clinic does not have the proper storage, count on your local pharmacy and clinics not having the right storage either. This is going to require massive cold storage upgrades that will carry a hefty cost.

Also consider that UPS, FedEx, and any other transportation companies tasked with shipping out the vaccines will have to upgrade their trucks and buy up large amounts of dry ice, which also happens to be in short supply right now.

The strict storage requirements almost certainly ensure that developing countries will likely not be able to utilize the Pfizer or Moderna vaccines. According to the Borgen Project, 166 countries are considered part of the developing world, with 52 of those countries located in Africa. To defeat the pandemic, all countries will need to have access to the vaccine.

https://youtu.be/-fm3RCFAwxU

Soligenix’s CiVax is Next-Gen Without the Logistical Headaches

Soligenix may not be receiving the same press attention as Pfizer or Moderna, but its COVID vaccine candidate is equally-if-not-more impressive. CiVax’s potential is unappreciated when considering the vaccine can be kept at room temperature, may only require one shot, and is based on a vaccine technology that has a history of tested safety and efficacy.

CiVax is Subunit Vaccine Focused on Th1 Antibody Response

CiVax is a subunit vaccine and thus does not use a live or dead virus. Subunit vaccines are derived from the proteins or glycoproteins of a virus. These proteins are the key components in producing a protective immune response.

Subunit vaccine technology already has a history of safety and, unlike mRNA technology, has already been approved by the U.S. FDA. The hepatitis B vaccine was the first subunit vaccine to be approved within the United States.

“Subunit vaccines are considered to be promising candidates for developing immunizations against malaria, tetanus, human cytomegalovirus, Salmonella enterica serovar Enteritidis infections, and even the novel severe acute respiratory syndrome coronavirus 2,” according to News Medical.

However, do not assume that CiVax is the typical subunit vaccine. CiVax has shown an ability to stimulate Th1 antibody responses. Th1 antibodies have proven to be effective to treat SARS and MERS, two closely related viruses to COVID-19. Assuming the Th1 antibody responses can be consistently produced against the new novel coronavirus, it could be likely that CiVax has similar effectiveness as the Pfizer or Moderna vaccines.

CiVax Shows Antibody-Neutralizing and Cell Immunity Abilities in One Shot

CiVax is seemingly superior to the Pfizer and Moderna vaccines because it has shown the ability to neutralize antibodies and produce cell immunity. Both of these factors are widely considered to be the key to developing a necessary and meaningful immune response.

Unlike the mRNA vaccines, CiVax showed these abilities after just one vaccination, rather than dealing with the need to obtain two shots over a specific period.

CiVax Can Be Stored At Room Temperature, Viable For Global Use

As discussed previously, the Moderna and Pfizer vaccines will seemingly only help developed countries that can upgrade cold storage capabilities. This means developing countries will be put at an extreme disadvantage.

With CiVax, there is no need for expensive cold storage upgrades. The vaccine is thermo-stabilized and thus can be stored at room temperature without losing potency. This makes CiVax far more viable not only for use in the developed world but also in the developing world.

Overall, a COVID-19 vaccine is required if the world is ever going to get back to any type of normality. However, the mRNA vaccines, such as those used in Pfizer’s and Moderna’s vaccines, seem to have lingering questions and concerns that will not be answered until it’s too late. The long-term safety and potential efficacy issues will likely not be discovered until millions or even billions of people have already been vaccinated.

Soligenix’s CiVax aims to provide a little more certainty and familiarity with the COVID vaccine arena. By using subunit vaccine technology with an established track record of safety and efficacy, CiVax could help provide ease to those that are concerned about the unknowns of the mRNA technology. The thermostabilized nature of CiVax is a win-win-win for patients, hospitals, and shippers, who will not have to rely on expensive cold storage upgrades, vaccine shelf-life, and potency worries. Also, the thermostabilized state of CiVax makes this a win for developing countries and thus gives life to the initiative of vaccinating the world against the COVID pandemic.

Disclaimer

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Fintech

How to identify authenticity in crypto influencer channels

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Modern brands stake on influencer marketing, with 76% of users making a purchase after seeing a product on social media.The cryptocurrency industry is no exception to this trend. However, promoting crypto products through influencer marketing can be particularly challenging. Crypto influencers pose a significant risk to a brand’s reputation and ROI due to rampant scams. Approximately 80% of channels provide fake statistics, including followers counts and engagement metrics. Additionally, this niche is characterized by high CPMs, which can increase the risk of financial loss for brands.

In this article Nadia Bubennnikova, Head of agency Famesters, will explore the most important things to look for in crypto channels to find the perfect match for influencer marketing collaborations.

 

  1. Comments 

There are several levels related to this point.

 

LEVEL 1

Analyze approximately 10 of the channel’s latest videos, looking through the comments to ensure they are not purchased from dubious sources. For example, such comments as “Yes sir, great video!”; “Thanks!”; “Love you man!”; “Quality content”, and others most certainly are bot-generated and should be avoided.

Just to compare: 

LEVEL 2

Don’t rush to conclude that you’ve discovered the perfect crypto channel just because you’ve come across some logical comments that align with the video’s topic. This may seem controversial, but it’s important to dive deeper. When you encounter a channel with logical comments, ensure that they are unique and not duplicated under the description box. Some creators are smarter than just buying comments from the first link that Google shows you when you search “buy YouTube comments”. They generate topics, provide multiple examples, or upload lists of examples, all produced by AI. You can either manually review the comments or use a script to parse all the YouTube comments into an Excel file. Then, add a formula to highlight any duplicates.

LEVEL 3

It is also a must to check the names of the profiles that leave the comments: most of the bot-generated comments are easy to track: they will all have the usernames made of random symbols and numbers, random first and last name combinations, “Habibi”, etc. No profile pictures on all comments is also a red flag.

 

LEVEL 4

Another important factor to consider when assessing comment authenticity is the posting date. If all the comments were posted on the same day, it’s likely that the traffic was purchased.

 

2. Average views number per video

This is indeed one of the key metrics to consider when selecting an influencer for collaboration, regardless of the product type. What specific factors should we focus on?

First & foremost: the views dynamics on the channel. The most desirable type of YouTube channel in terms of views is one that maintains stable viewership across all of its videos. This stability serves as proof of an active and loyal audience genuinely interested in the creator’s content, unlike channels where views vary significantly from one video to another.

Many unauthentic crypto channels not only buy YouTube comments but also invest in increasing video views to create the impression of stability. So, what exactly should we look at in terms of views? Firstly, calculate the average number of views based on the ten latest videos. Then, compare this figure to the views of the most recent videos posted within the past week. If you notice that these new videos have nearly the same number of views as those posted a month or two ago, it’s a clear red flag. Typically, a YouTube channel experiences lower views on new videos, with the number increasing organically each day as the audience engages with the content. If you see a video posted just three days ago already garnering 30k views, matching the total views of older videos, it’s a sign of fraudulent traffic purchased to create the illusion of view stability.

 

3. Influencer’s channel statistics

The primary statistics of interest are region and demographic split, and sometimes the device types of the viewers.

LEVEL 1

When reviewing the shared statistics, the first step is to request a video screencast instead of a simple screenshot. This is because it takes more time to organically edit a video than a screenshot, making it harder to manipulate the statistics. If the creator refuses, step two (if only screenshots are provided) is to download them and check the file’s properties on your computer. Look for details such as whether it was created with Adobe Photoshop or the color profile, typically Adobe RGB, to determine if the screenshot has been edited.

LEVEL 2

After confirming the authenticity of the stats screenshot, it’s crucial to analyze the data. For instance, if you’re examining a channel conducted in Spanish with all videos filmed in the same language, it would raise concerns to find a significant audience from countries like India or Turkey. This discrepancy, where the audience doesn’t align with regions known for speaking the language, is a red flag.

If we’re considering an English-language crypto channel, it typically suggests an international audience, as English’s global use for quality educational content on niche topics like crypto. However, certain considerations apply. For instance, if an English-speaking channel shows a significant percentage of Polish viewers (15% to 30%) without any mention of the Polish language, it could indicate fake followers and views. However, if the channel’s creator is Polish, occasionally posts videos in Polish alongside English, and receives Polish comments, it’s important not to rush to conclusions.

Example of statistics

 

Wrapping up

These are the main factors to consider when selecting an influencer to promote your crypto product. Once you’ve launched the campaign, there are also some markers to show which creators did bring the authentic traffic and which used some tools to create the illusion of an active and engaged audience. While this may seem obvious, it’s still worth mentioning. After the video is posted, allow 5-7 days for it to accumulate a basic number of views, then check performance metrics such as views, clicks, click-through rate (CTR), signups, and conversion rate (CR) from clicks to signups.

If you overlooked some red flags when selecting crypto channels for your launch, you might find the following outcomes: channels with high views numbers and high CTRs, demonstrating the real interest of the audience, yet with remarkably low conversion rates. In the worst-case scenario, you might witness thousands of clicks resulting in zero to just a few signups. While this might suggest technical issues in other industries, in crypto campaigns it indicates that the creator engaged in the campaign not only bought fake views and comments but also link clicks. And this happens more often than you may realize.

Summing up, choosing the right crypto creator to promote your product is indeed a tricky job that requires a lot of resources to be put into the search process. 

Author Nadia Bubennikova, Head of agency  at Famesters

Author

Nadia Bubennikova, Head of agency at Famesters

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Fintech

Central banks and the FinTech sector unite to change global payments space

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The BIS, along with seven leading central banks and a cohort of private financial firms, has embarked on an ambitious venture known as Project Agorá.

Named after the Greek word for “marketplace,” this initiative stands at the forefront of exploring the potential of tokenisation to significantly enhance the operational efficiency of the monetary system worldwide.

Central to this pioneering project are the Bank of France (on behalf of the Eurosystem), the Bank of Japan, the Bank of Korea, the Bank of Mexico, the Swiss National Bank, the Bank of England, and the Federal Reserve Bank of New York. These institutions have joined forces under the banner of Project Agorá, in partnership with an extensive assembly of private financial entities convened by the Institute of International Finance (IIF).

At the heart of Project Agorá is the pursuit of integrating tokenised commercial bank deposits with tokenised wholesale central bank money within a unified, public-private programmable financial platform. By harnessing the advanced capabilities of smart contracts and programmability, the project aspires to unlock new transactional possibilities that were previously infeasible or impractical, thereby fostering novel opportunities that could benefit businesses and consumers alike.

The collaborative effort seeks to address and surmount a variety of structural inefficiencies that currently plague cross-border payments. These challenges include disparate legal, regulatory, and technical standards; varying operating hours and time zones; and the heightened complexity associated with conducting financial integrity checks (such as anti-money laundering and customer verification procedures), which are often redundantly executed across multiple stages of a single transaction due to the involvement of several intermediaries.

As a beacon of experimental and exploratory projects, the BIS Innovation Hub is committed to delivering public goods to the global central banking community through initiatives like Project Agorá. In line with this mission, the BIS will soon issue a call for expressions of interest from private financial institutions eager to contribute to this ground-breaking project. The IIF will facilitate the involvement of private sector participants, extending an invitation to regulated financial institutions representing each of the seven aforementioned currencies to partake in this transformative endeavour.

Source: fintech.globa

The post Central banks and the FinTech sector unite to change global payments space appeared first on HIPTHER Alerts.

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TD Bank inks multi-year strategic partnership with Google Cloud

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TD Bank has inked a multi-year deal with Google Cloud as it looks to streamline the development and deployment of new products and services.

The deal will see the Canadian banking group integrate the vendor’s cloud services into a wider portion of its technology solutions portfolio, a move which TD expects will enable it “to respond quickly to changing customer expectations by rolling out new features, updates, or entirely new financial products at an accelerated pace”.

This marks an expansion of the already established relationship between TD Bank and Google Cloud after the group previously adopted the vendor’s Google Kubernetes Engine (GKE) for TD Securities Automated Trading (TDSAT), the Chicago-based subsidiary of its investment banking unit, TD Securities.

TDSAT uses GKE for process automation and quantitative modelling across fixed income markets, resulting in the development of a “data-driven research platform” capable of processing large research workloads in trading.

Dan Bosman, SVP and CIO of TD Securities, claims the infrastructure has so far supported TDSAT with “compute-intensive quantitative analysis” while expanding the subsidiary’s “trading volumes and portfolio size”.

TD’s new partnership with Google Cloud will see the group attempt to replicate the same level of success across its entire portfolio.

Source: fintechfutures.com

The post TD Bank inks multi-year strategic partnership with Google Cloud appeared first on HIPTHER Alerts.

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