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Anbogen Secures 12.5 Million in Series A Funding, Advancing Precision Oncology Drug Development

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TAIPEI, Jan. 31, 2024 /PRNewswire/ — Anbogen Therapeutics, a clinical-stage biotechnology company specializing in groundbreaking cancer drug development, today announced the successful completion of its Series A funding round. The lead investor is China Development Industrial Bank (CDIB), with significant contributions from Taian Venture Capital, Maxpro and the National Development Fund (Business Angel Investment Program, and Implementation Project for Strengthening Investment in SMEs), with a total investment of approximately 12.5 million. The raised capital will be directed towards the ongoing development of Anbogen’s two main drug candidates, ABT-101 and ABT-301. It is worth mentioning that both of these candidate drugs were supported by the National Research Program for Biopharmaceuticals (NRPB) before Anbogen took over. With the continued endeavor from Anbogen, these candidate drugs are steadily advancing in clinical trials for evaluation of their efficacy.

ABT-101, a HER2-targeting tyrosine kinase inhibitor (TKI), has exhibited substantial potency and safety during its pre-clinical and phase 1b clinical trial. During the pre-clinical study, ABT-101 demonstrated superior selectivity against HER2 exon20 insertion mutation. In the Phase 1b trial, Dr. Tsu-An Hsu, CEO of Anbogen, stated, “Signs of safety and clinical benefits have been observed in non-small cell lung cancer patients, including sustained tumor suppression in patients who previously developed resistance to Enhertu treatment.” ABT-101 has completed the DLT evaluation of 3 dosage groups (100 mg, 150 mg, and 200 mg), and is now advancing to the 250 mg cohort in the phase 1b trial to continue evaluation of safety, tolerability, pharmacokinetics and efficacy. Phase 2 is scheduled to commence upon the completion of phase 1 trial in 2024.

Joe Hsueh, Anbogen’s General Manager, stated, “With bioventure investors support, we aim to expedite ABT-101 development and broaden its use across various solid tumor types (including colorectal, biliary tract, breast, urothelial, and other gastrointestinal cancers) through our basket trial. Furthermore, the integration of Next-Generation Sequencing (NGS) will facilitate our efforts in developing precision medicine for cancers with unmet clinical need, making a substantial contribution to the advancement of the field.”

Additionally, Anbogen is actively progressing ABT-301, a novel small molecule drug that potentiates efficacy of immune checkpoint inhibitors (ICIs). Having completed its phase 1 trial, ABT-301 exhibited superior safety and pharmacokinetic profiles compared to other marketed drugs with similar mechanism of action. Repeated animal studies reveal a surprising synergistic effect when ABT-301 is used in combination with immune ICIs (anti-PD1/anti-PD-L1) in animal models including colorectal cancer of microsatellite stable (MSS). ABT-301 can modulate the tumor microenvironment, increase the number of killer T cells in peripheral blood and infiltrating the tumor, enabling ICIs to overcome the limitations of “cold” tumors and produce immunotherapeutic effects. Additionally, remarkable efficacy of such combination was observed in head and neck cancer, triple-negative breast cancer (TNBC) and liver cancer animal models. Based on these results, Anbogen has initiated preparations for the Phase 2 clinical trial of ABT-301, combining it with ICIs for the treatment of cancer patients.

Furthermore, leveraging years of experience in developing small molecule cancer drugs, Anbogen’s R&D team independently developed the ABT-200 series of small molecule inhibitors targeting pan-KRAS gene mutations. The ABT-200 series is an exciting development in the field of cancer treatment, showing promising advancements in its early stages. This series holds tremendous potential for addressing cancers that currently lack approved KRAS-targeted drugs, including pancreatic cancer and colorectal cancer.

The Series A funding not only reflects the value of Anbogen’s innovative pipeline, but also underscores the company’s commitment to advancing cancer treatment to fulfill the unmet medical needs.

About Anbogen:

Anbogen is a clinical-stage biotechnology company dedicated to developing precision anti-cancer drugs that hold the/promise of curing cancers and/or improving the lives of cancer patients worldwide. Anbogen, whose founding was proposed by Dr. Joe Shih, aligns with national policies and addresses significant medical needs. We prioritize innovative research and development for diverse cancer types. For more information, please visit www.anbogen.com.

For Media Inquiries, Please Contact:
Angus Wu
Business Development, Vice President
[email protected]

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Delta Consulting Group Elevates Jeffrey Fuchs to Executive Chairman and Appoints Darin L. Buchalter as Chief Executive Officer

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WASHINGTON, Jan. 8, 2025 /PRNewswire/ — Delta Consulting Group, an employee-owned expert advisory consultancy specializing in construction, forensics, investigations and valuation, announced today the elevation of Jeffrey Fuchs to Executive Chairman and Darin L. Buchalter as its new Chief Executive Officer. These leadership changes underscore Delta’s commitment to continued strategic growth, delivering exceptional results for its global clients, and cultivating a positive, supportive, and fulfilling work environment for its employees.

Jeff Fuchs, Delta co-founder, will continue to provide expert services, deliver strategic guidance, foster strong relationships with key clients, and champion the company’s core values — principles that have been the foundation of Delta’s success over the past 25 years. Under his leadership, Delta has grown organically, expanded through strategic acquisitions, and cultivated top talent, evolving into a comprehensive provider of forensics, investigative, and dispute resolution services. The firm has earned a prominent reputation and was honored as a Top Workplace by The Washington Post in 2024.

Since 2022, Darin Buchalter has played a pivotal role in guiding transformative growth strategies for Delta as a member of its Strategic Advisory Board. His contributions include driving service line expansion, enhancing the company’s global market presence, and ensuring the continuity of high-quality service for clients.

“Darin is a dynamic leader with a deep understanding of our business, a proven track record of delivering results, and an unwavering commitment to our mission and values,” said Jeff Fuchs. “This transition reflects the strength of our leadership pipeline and the deliberate planning that positions Delta to excel in a rapidly evolving industry landscape.”

Darin brings over 20 years as a successful senior executive, global business leader, and independently recognized expert at leading business advisory and professional services firms, as well as experience as a C-level executive and board member in complex, high value transformation. As leader of the Global Construction Practice at Navigant Consulting, Inc., he expanded markets, adjacent service lines, geographies, and impactful offerings for clients, making the business into one of the largest operators in the sector. Following Navigant’s carveout and combination with Ankura Consulting Group, he led the newly merged disputes, investigations, and expert services practices across the global legal, risk, and compliance marketplace, spanning four continents. Later, as Ankura’s Chief Administrative Officer, he successfully positioned the newly formed company as a highly profitable and rapidly growing consultancy. Darin’s career foundation is in Big 4 consulting as a Partner at EY.

“I am honored to step into this role and lead Delta,” said Darin. “With the exceptional talent of our employee-owners, the support of our Board, and the solid foundation Jeff has built, we are well positioned to seize new opportunities, exceed our client’s expectations, and drive sustainable growth for our stakeholders.”

“As we embark on this new chapter, we remain steadfast in our commitment to the core values that have been the cornerstone of our success,” Jeff added. “With Darin’s vision and leadership, Delta is well-positioned to continue thriving, fostering a culture of excellence and innovation that will propel us into the future.”

About Delta Consulting Group

Since 2000, Delta Consulting Group has provided advisory, risk mitigation and dispute resolution services with prominent global law firms, government agencies, and top companies in over 90 countries. Our multi-disciplined professionals in engineering, accounting, finance, economics, investigations, fraud, construction, project management and litigation support deliver independent advice to resolve our clients’ most complex situations.  Delta is a 100% employee-owned company and was named a 2024 Top Workplace by The Washington Post.

To learn more about Delta please visit delta-cgi.com.

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Aon appoints John Neal as Global Chairman of Climate Solutions and Global CEO of Reinsurance

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  • New global climate role will help tackle increasing weather and catastrophe risks through advanced analytics, innovative solutions and new sources of capital
  • Proven entrepreneurial leader with international experience across Reinsurance and Commercial Risk strengthens the firm’s industry-leading integrated Risk Capital capability

DUBLIN, Jan. 8, 2025 /PRNewswire/ — Aon plc (NYSE: AON), a leading global professional services firm, announced today the appointment of John Neal as Global Chairman of Climate Solutions and Global CEO of Reinsurance for Aon, effective following the conclusion of his notice period.

Neal will help lead Aon’s efforts to address the growing and complex risks associated with climate change, while also building on the success of the firm’s industry-leading Reinsurance team, further enhancing the value Aon delivers to clients. His appointment arrives at a critical time as businesses and communities around the world must tackle increasing volatility driven by climate-related events, and as Aon continues to leverage its integrated Risk Capital capabilities to offer the firm’s clients advanced analytics, innovative solutions and access to new sources of capital. Neal will play an important role in delivering Reinsurance solutions to meet the evolving demands of today’s dynamic marketplace. He will be based in London, reporting to Andy Marcell, CEO of Risk Capital for Aon, and serve as a member of the firm’s Risk Capital leadership team.

“John’s career is celebrated for looking ahead to the future and investing in technology and talent to position the insurance industry for greater impact and growth,” said Greg Case, CEO of Aon. “He brings significant and relevant experience that will advance our 3×3 Plan to accelerate our Aon United strategy, unlock integrated climate solutions and ultimately create key points of difference in how we serve our clients across risk and people issues.”

Neal will join Aon from Lloyd’s of London (Lloyd’s), the world’s leading insurance marketplace, where he has served as CEO since October 2018. During his tenure, Lloyd’s experienced a remarkable transformation, achieving industry-leading performance and the company’s strongest financial position in its 340-year history. His strategic initiatives helped position the company for long-term growth and sustainability, while reinforcing the vital role the insurance industry plays in helping clients navigate risks — from geopolitical volatility to climate change.

Marcell said, “I’m excited to welcome John to Aon. He brings a wealth of experience, strategic vision and a deep understanding of the shifting needs of our clients. His leadership will be instrumental in supporting the team to address the challenges organizations face across the megatrends of Trade, Technology, Weather and Workforce, and developing solutions that enable our clients to thrive in a rapidly changing world.”

Neal added, “I will be forever grateful to my colleagues and many others across the Lloyd’s market for the opportunity to put in place a framework that has delivered strong and sustainable financial performance and positions Lloyd’s for future success. At Aon, I’m looking forward to supporting colleagues as they look to serve clients’ reinsurance needs and deliver smart insurance solutions that help address some of the world’s most pressing challenges, especially with regard to the climate transition.”

Prior to joining Lloyd’s, Neal served as Group CEO of QBE, a global insurance and reinsurance business, where he was responsible for running a $14 billion gross written premium (GWP) business with over 14,000 employees in 37 countries. Before becoming CEO, he held a number of leadership positions at QBE, including Chief Underwriting Officer and Chief Operations Officer of the firm’s European operations. Previously, he led a management buyout of Ensign to establish a dedicated Lloyd’s Managing Agency. As CEO of Ensign, he grew GWP to $300 million to create the leading specialist commercial motor underwriter in the UK. He also worked at Bankside Managing Agency, where he was the youngest active underwriter at Lloyd’s, and started his career at the Crowe Underwriting Agency.

About Aon
Aon plc (NYSE: AON) exists to shape decisions for the better — to protect and enrich the lives of people around the world. Through actionable analytic insight, globally integrated Risk Capital and Human Capital expertise, and locally relevant solutions, our colleagues provide clients in over 120 countries and sovereignties with the clarity and confidence to make better risk and people decisions that protect and grow their businesses.

Follow Aon on LinkedInXFacebook and Instagram. Stay up-to-date by visiting Aon’s newsroom and sign up for news alerts here.

Media Contact
[email protected]
Toll-free (U.S., Canada and Puerto Rico): +1 833 751 8114
International: +1 312 381 3024

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Miami International Holdings Reports Trading Results for December and Full-Year 2024; MIAX Exchange Group Sets Multiple Volume and Market Share Records in Options and Equities Markets

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MIAMI AND PRINCETON, N.J., Jan. 8, 2025 /PRNewswire/ — Miami International Holdings, Inc. (MIH), a technology-driven leader in building and operating regulated financial markets across multiple asset classes, today reported December and full-year 2024 trading results for its U.S. exchange subsidiaries – MIAX®, MIAX Pearl®, MIAX Emerald® and MIAX SapphireTM (collectively, the MIAX Exchange Group), and MIAX FuturesTM.

December 2024 and Full-Year 2024 Trading Volume and Market Share Highlights

  • Total multi-listed options volume for the MIAX Exchange Group reached a record 1.7 billion contracts in 2024, a 6.5% increase year-over-year (YoY) and representing an annual market share of 15.1%, a 3.8% decrease YoY. December volume totaled a record 165.6 million contracts, a 29.1% increase YoY and representing a monthly market share of 16.4%, a 6.0% increase YoY.
  • MIAX Sapphire reached a volume of 65.0 million contracts in 2024, following its launch on August 12, 2024. December volume reached 18.4 million contracts, with December market share reaching 1.8%.
  • MIAX Options reached a record volume of 691.6 million contracts in 2024, a 9.1% increase YoY and representing an annual market share of 6.2%, a 1.5% decrease YoY. December volume reached 63.4 million contracts, a 23.3% increase YoY and representing a monthly market share of 6.3%, a 1.3% increase YoY.
  • MIAX Pearl Options reached a volume of 468.0 million contracts in 2024, a 27.7% decrease YoY and representing a market share of 4.2%, a 34.7% decrease YoY. December volume totaled 31.3 million contracts, a 32.5% decrease YoY and representing a monthly market share of 3.1%, a 44.5% decrease YoY.
  • MIAX Emerald reached a record volume of 465.6 million contracts in 2024, a 52.2% increase YoY and representing a record market share of 4.2%, a 37.4% increase YoY. December volume reached a record 52.5 million contracts, a 72.0% increase YoY and representing a monthly market share of 5.2%, a 41.3% increase YoY.
  • In U.S. equities, MIAX Pearl Equities™ reached a record volume of 49.9 billion shares in 2024, a 6.2% increase YoY and representing a market share of 1.6%, a 4.4% decrease YoY. December volume totaled 3.8 billion shares, a 12.8% decrease YoY and representing a market share of 1.2%, a 30.0% decrease YoY.
  • In U.S. futures, MIAX Futures, a Designated Contract Market (DCM) and Derivatives Clearing Organization (DCO), reached a record volume of 3.2 million contracts in 2024, a 10.2% increase YoY. December volume reached 197,513 contracts, a 44.5% increase YoY.

Additional MIAX Exchange Group and MIAX Futures trading volume and market share information are included in the tables below. 

Multi-Listed Options Trading Volume for

 MIAX Exchange Group, Current Month

Year-to-Date Comparison

Multi-Listed Options
Contracts

Dec-24

Dec-23

% Chg

Nov-24

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% Chg

Dec-24

Dec-23

% Chg

Trading Days

21

20

20

252

250

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U.S. Equity Options Industry

1,011,972,009

831,449,638

21.7 %

1,010,941,318

0.1 %

11,178,827,232

10,092,147,417

10.8 %

MIAX Exchange Group

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165,584,587

128,287,450

29.1 %

163,035,002

1.6 %

1,690,222,589

1,587,012,460

6.5 %

MIAX Options

63,396,610

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51,400,676

23.3 %

60,797,990

4.3 %

691,609,824

634,026,200

9.1 %

MIAX Pearl

31,298,746

46,372,764

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-32.5 %

32,006,908

-2.2 %

468,016,859

647,128,959

-27.7 %

MIAX Emerald

52,472,586

30,514,010

72.0 %

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51,730,078

1.4 %

465,577,123

305,857,301

52.2 %

MIAX Sapphire(1)

18,416,645

0. -0%

18,500,026

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-0.5 %

65,018,783

Multi-Listed Options ADV

Dec-24

Dec-23

% Chg

Nov-24

% Chg

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Dec-24

Dec-23

% Chg

U.S. Equity Options Industry

48,189,143

41,572,482

15.9 %

50,547,066

-4.7 %

44,360,426

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40,368,590

9.9 %

MIAX Exchange Group

7,884,980

6,414,373

22.9 %

8,151,750

-3.3 %

6,707,232

6,348,050

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5.7 %

MIAX Options

3,018,886

2,570,034

17.5 %

3,039,900

-0.7 %

2,744,483

2,536,105

8.2 %

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MIAX Pearl

1,490,416

2,318,638

-35.7 %

1,600,345

-6.9 %

1,857,210

2,588,516

-28.3 %

MIAX Emerald

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2,498,695

1,525,701

63.8 %

2,586,504

-3.4 %

1,847,528

1,223,429

51.0 %

MIAX Sapphire(1)

876,983

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925,001

-5.2 %

258,011

Multi-Listed Options Market Share for

MIAX Exchange Group, Current Month

Year-to-Date Comparison

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Multi-Listed Options Market
Share

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

Dec-23

% Chg

MIAX Exchange Group

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16.36 %

15.43 %

6.0 %

16.13 %

1.5 %

15.12 %

15.73 %

-3.8 %

MIAX Options

6.26 %

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6.18 %

1.3 %

6.01 %

4.2 %

6.19 %

6.28 %

-1.5 %

MIAX Pearl

3.09 %

5.58 %

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-44.5 %

3.17 %

-2.3 %

4.19 %

6.41 %

-34.7 %

MIAX Emerald

5.19 %

3.67 %

41.3 %

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5.12 %

1.3 %

4.16 %

3.03 %

37.4 %

MIAX Sapphire(1)

1.82 %

1.83 %

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-0.6 %

0.58 %

(1)

MIAX Sapphire launched trading on August 12, 2024, listing a single class for the first week and additional classes in multiple phases on a weekly schedule through the week of October 21, 2024. 

 

Equities Trading Volume for

MIAX Pearl Equities, Current Month

Year-to-Date Comparison

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Equities Shares (millions)

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

Dec-23

% Chg

Trading Days

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21

20

20

252

250

U.S. Equities Industry

308,866

247,729

24.7 %

292,020

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5.8 %

3,064,080

2,758,344

11.1 %

MIAX Pearl Volume

3,827

4,387

-12.8 %

3,767

1.6 %

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49,865

46,935

6.2 %

MIAX Pearl ADV

182

219

-16.9 %

188

-3.3 %

198

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188

5.4 %

MIAX Pearl Market Share

1.24 %

1.77 %

-30.0 %

1.29 %

-4.0 %

1.63 %

1.70 %

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-4.4 %

Futures and Options Trading Volume and Open Interest for MIAX
Futures, Current Month

Year-to-Date Comparison

Futures & Options Contracts

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

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Dec-23

% Chg

Trading Days

21

20

20

252

250

MIAX Futures Volume

197,513

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136,652

44.5 %

342,348

-42.3 %

3,188,735

2,894,831

10.2 %

MIAX Futures ADV

9,405

6,833

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37.7 %

17,117

-45.1 %

12,654

11,579

9.3 %

MIAX Futures Open Interest

96,634

63,238

52.8 %

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82,183

17.6 %

About MIAX
MIAX’s parent holding company, Miami International Holdings, Inc., owns Miami International Securities Exchange, LLC (MIAX®), MIAX PEARL, LLC (MIAX Pearl®), MIAX Emerald, LLC (MIAX Emerald®), MIAX Sapphire LLC (MIAX SapphireTM), MIAX Futures Exchange, LLC (MIAX FuturesTM), MIAX Derivatives Exchange (MIAXdxTM), The Bermuda Stock Exchange (BSX) and Dorman Trading, LLC (Dorman Trading).

MIAX, MIAX Pearl, MIAX Emerald and MIAX Sapphire are national securities exchanges registered with the Securities and Exchange Commission that are enabled by MIAX’s in-house built, proprietary technology. MIAX offers trading of options on all four exchanges as well as cash equities through MIAX Pearl Equities™. The MIAX trading platform was built to meet the high-performance quoting demands of the U.S. options trading industry and is differentiated by throughput, latency, reliability and wire-order determinism.

MIAX Futures is a registered exchange with the Commodity Futures Trading Commission (CFTC) and offers trading in a variety of products including Hard Red Spring Wheat Futures. MIAX Futures is a Designated Contract Market (DCM) and Derivatives Clearing Organization (DCO) under the CFTC, providing DCM and DCO services in an array of asset classes.

MIAXdx is a CFTC regulated exchange and clearinghouse and is registered as a Designated Contract Market (DCM), Derivatives Clearing Organization (DCO), and Swap Execution Facility (SEF) with the CFTC.

BSX is a fully electronic, vertically integrated international securities market headquartered in Bermuda and organized in 1971. BSX specializes in the listing and trading of capital market instruments such as equities, debt issues, funds, hedge funds, derivative warrants, and insurance linked securities.

Dorman Trading is a full-service Futures Commission Merchant registered with the CFTC.

MIAX’s executive offices and National Operations Center are located in Princeton, N.J., with additional U.S. offices located in Chicago, IL and Miami, FL. MIAX Futures offices are located in Minneapolis, MN. MIAXdx offices are located in Princeton, N.J. BSX offices are located in Hamilton, Bermuda. Dorman Trading offices are located in Chicago, IL.

To learn more about MIAX visit www.miaxglobal.com.

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To learn more about MIAX Futures visit www.miaxglobal.com/miax-futures.

To learn more about MIAXdx visit www.miaxdx.com.

To learn more about BSX visit www.bsx.com.

To learn more about Dorman Trading visit www.dormantrading.com.

Disclaimer and Cautionary Note Regarding Forward-Looking Statements
The press release shall not constitute an offer to sell or a solicitation of an offer to purchase any securities of Miami International Holdings, Inc. (together with its subsidiaries, the Company), and shall not constitute an offer, solicitation or sale in any state or jurisdiction in which such offer; solicitation or sale would be unlawful. This press release may contain forward-looking statements, including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements describe future expectations, plans, results, or strategies and are generally preceded by words such as “may,” “future,” “plan” or “planned,” “will” or “should,” “expected,” “anticipates,” “draft,” “eventually” or “projected.” You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements.

All third-party trademarks (including logos and icons) referenced by the Company remain the property of their respective owners. Unless specifically identified as such, the Company’s use of third-party trademarks does not indicate any relationship, sponsorship, or endorsement between the owners of these trademarks and the Company. Any references by the Company to third-party trademarks is to identify the corresponding third-party goods and/or services and shall be considered nominative fair use under the trademark law.

Media Contact:
Andy Nybo, SVP, Chief Communications Officer
(609) 955-2091
[email protected]

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