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NeoPhore raises an additional £9.6m (USD $12.2m) Series B financing extension to further progress drug discovery pipeline

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  • Italian investors, NEVA SGR, LIFTT and Simon Fiduciaria, join the existing syndicate
  • Additional investment brings the total Series B financing to £31.1 million (approx. USD $39.5 million)

LONDON, Feb. 1, 2024 /PRNewswire/ — NeoPhore Limited, a small molecule neoantigen immuno-oncology company, today announces a further extension of £9.6m (approx. USD $12.2m) to its Series B financing round. With participation from its existing syndicate, CPF managed by Sixth Element Capital, Claris Ventures, Astellas Venture Management, 3B Future Health Fund, 2investAG, and the addition of three new investors – NEVA SGR (the venture capital arm of Intesa Sanpaolo banking group), LIFTT (the venture capital focused on deep-tech chaired by Stefano Buono) and Simon Fiduciaria (the fiduciary company of Ersel Group). This extension brings the total raised in Series B financing to £31.1m (approx. USD $39.5m).

NeoPhore is building a pipeline of small molecule drugs targeting novel proteins across the DNA mismatch repair (‘MMR’) pathway to generate next-generation immuno-oncology therapeutics to improve clinical outcomes for cancer patients. NeoPhore’s first-in-class MMR inhibitors induce neoantigen expression and increase immunogenicity in solid tumours that become exquisitely sensitive to immunotherapy.

2023 was a great year of progress for NeoPhore. At AACR-NCI-EORTC in Boston in October, the first disclosure of lead compound NP1867 was presented. This demonstrated that NP1867 functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples.

The additional Series B funding will be used to progress NeoPhore’s lead oral program, through early pre-clinical development.

Dr Matthew Baker, Chief Executive Officer of NeoPhore, said: “NeoPhore has made excellent progress throughout 2023. With the support of our committed and new investors, along with our research collaborations with academic institutions that are in place, we remain on track to deliver a candidate drug for our lead PMS2 program by early 2025.”

Dr Robert James, Chairman of NeoPhore, said: “Over the past years NeoPhore has made tremendous strides in showing that it is possible to target the MMR pathway with small molecule inhibitors.  The recent data the Company has generated and presented at an international conference leads us to believe that NeoPhore’s approach may be profoundly important.  We are pleased to welcome three new Italian-based investors to our syndicate as well as further funding from existing investors. Their commitment reflects the potential value of NeoPhore’s approach that exploits the dynamics of cancer neoantigen evolution, through the discovery and design of effective, well-tolerated medicines that will become a key part of the next-generation of cancer immunotherapies. We are very excited about the next stage in the life of the Company.”

About NeoPhore Ltd

NeoPhore, UK is focused on the discovery and development of novel small molecule therapies to treat cancer through stimulation of the immune system. Generation of cancer neoantigens in tumours can be exploited by the patients’ immune system to overcome natural defence mechanisms in cancer. The Company’s approach targets the DNA mismatch repair (MMR) pathway, which has been proven to promote neoantigen creation and subsequent immunity against numerous cancers. Using these insights, NeoPhore aims to generate next-generation immuno-oncology therapeutics to improve clinical outcomes for cancer patients. NeoPhore was spun-out of the University of Turin and PhoreMost Ltd by the CRT Pioneer Fund. For more information, please visit www.neophore.com

About NEVA SGR

Neva SGR, venture capital arm of the Intesa Sanpaolo Group and wholly owned by the Intesa Sanpaolo Innovation Center, plans and manages investment funds for professional investors interested in seizing diversification and high-yield opportunities offered by Venture Capital investments. Neva SGR can count on Intesa Sanpaolo Innovation Center’s and Intesa Sanpaolo Group’s strength, financial resources, know-how and network of relationships, a unique source of value on the market. Neva SGR can watch trends and markets from a privileged position and takes action with the strength and the responsibility of Italy’s leading banking group. Intesa Sanpaolo Innovation Center has invested in Neva First, the investment fund designed for excellent, high-tech, high-innovation start-ups, which take advantage of trends with exponential growth potential.

To learn more visit www.nevasgr.com

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About LIFTT

Chaired by the scientist and entrepreneur Stefano Buono, LIFTT’s aim is to encourage technology development and transfer from University to Industry, but also to clear the way from a simple business idea to the creation of an innovative product, offering a dynamic and modern vision of venture capital as applied to Technology Transfer. To date, LIFTThas raised EUR 103,5 million and has completed 47 investments, from a pipeline of +3000 companies, operating in all market sectors, with a particular focus on Deep Tech. www.liftt.com Head of Communications & Investor relations: [email protected]

About Simon Fiduciaria

Simon Fiduciaria is the fiduciary and trust company of Ersel Group which since 1936 has been a specialist in wealth management and a unique company in Italy for its absolute independence, professionalism, quality of service, and direct and personal relationship with the client.

Founded in 1986, Simon Fiduciaria stands out for its independence as well as its operational and professional qualities, to fully meet the needs of its customers. As a reference point for the Italian fiduciary market, with over 7 billion administered assets, Simon Fiduciaria has developed, alongside fiduciary and trust heading services, an innovative service dedicated to large private and institutional assets, with independent and analytical monitoring that offers an aggregated view of allocation, performance, and risks, and highlights potential areas for improvement.

About Sixth Element Capital LLP and the CRT Pioneer Fund

Sixth Element Capital LLP (6EC) is a UK based fund manager, which manages the CRT Pioneer Fund. 6EC’s experienced partners focus on creative and collaborative novel financing solutions designed to fund and manage innovative science in order to bring new therapeutic products and technologies to market, creating long term value and benefit to stakeholders. The CRT Pioneer Fund is a specialist oncology investment fund established by 6EC in 2012. The £70 million fund is dedicated to investments in oncology development programmes in Europe. The fund was established to bridge the investment gap between cancer drug discovery and early clinical development.

For more information, please see www.sixthelementcapital.com

About Claris Ventures

Claris Ventures is a biotech-focused venture capital firm based in Turin (Italy). Its first fund under management, Claris Biotech I, was launched in 2020 to finance high potential biopharma companies arisen from the Italian R&D ecosystem – both local and international. We identify and support innovation in the pharmaceutical space, investing in new companies with transformational drugs under development. We aim at the highest impact possible on highly unmet patients’ needs, building value around strong science. Our pursuit for high potential projects involves every research center, clinical structure and company in the Italian life sciences network, whether the founding team is based in Italy or it includes Italian scientists abroad who have strong links with Italy.

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http://www.clarisventures.com/

About 3B Future Health Fund II

3B Future Health Fund II S.C.A. SICAV-RAIF is a Luxembourg based investment fund investing in oncology and rare disease therapeutics in Europe and the United States. The firm’s goal is to identify innovative and promising companies that are developing First-in-Class therapeutics for indications with high unmet patient needs and provide them with the financial resources and strategic guidance they need to succeed. The fund targets companies with strong management teams, a solid scientific foundation, and a clear path to regulatory approval and commercialization. We seek to invest in early-stage companies with promising preclinical data. Additionally, the fund’s investment team has extensive experience in the pharma industry, a track record of success in drug development and identifying high-potential investments. 3B is committed to creating value for its investors while also making a positive impact on the lives of patients. For more information please see www.3bfuturehealth.com

About Astellas Venture Management LLC

Astellas Venture Management LLC (AVM) is the corporate venture capital organization dedicated to reinforcing Astellas Pharma Inc. (Astellas) to accomplish the strategic goals. The venture capital activity of AVM is designated since 2005. Astellas, the ultimate parent company of AVM, headquartered in Tokyo is actively engaged in business as an R&D-driven global pharmaceutical company with the business philosophy to “Contribute toward improving the health of people around the world through the provision of innovative and reliable pharmaceutical products”. Through strategic investments in private early-stage companies, the funds aim to mutual-interact with Astellas, leading to partnering/collaboration in the future. AVM will be able to provide portfolio companies with invaluable R&D advice and assistance.

About 2Invest

2Invest AG (2Invest) is an investment company listed on Frankfurt market formed in 2020 from the restructuring of businesses of 4basebio AG.  Our investment objective is primarily but not exclusively to identify and support emerging companies with both strong management teams and ground-breaking technologies in the biotechnology, life sciences and IT sectors. Our ambition is to enable those companies to reach new and meaningful value inflexion points.

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GCash enables seamless linkage of Overseas Filipino remittances with UK and EU bank cash in

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MANILA, Philippines, Nov. 26, 2024 /PRNewswire/ — GCash, the Philippines’ leading finance super app and largest cashless ecosystem, further expands its presence overseas, particularly in the United Kingdom and Europe, through the new UK/EU Bank Cash In feature, revolutionizing remittance for around two million Filipinos in Europe.

Starting in November, overseas Filipinos in the UK and Europe will be able to seamlessly link their international bank accounts to GCash, making it easier and more convenient to send remittances to the Philippines.

Previously, sending money from the UK and Europe to the Philippines has been a complex and time-consuming process, often involving expensive fees and multiple intermediaries. With the new feature, Filipinos can enjoy lower fees and faster transaction times when sending money home, as well as competitive exchange rates and real-time access to funds.

“Many Filipinos have chosen Europe and the United Kingdom as their home. GCash hopes to provide their needs and help them connect with their loved ones, as a trusted digital finance partner made for Filipinos, by Filipinos,” said Paul Albano, GCash International General Manager.

Floris de Kort, CEO of Thunes, added, “We are expanding our collaboration with GCash, a long-standing valued Member of our Direct Global Network, to transform digital wallet top-ups. Through Thunes’ Direct Global Network, we are now delivering an instant top-up service that simplifies cross-border transactions. Our alliance with GCash is a testament to our passion for innovation, the versatility of our proprietary network, and our dedication to financial inclusion through money movement around the world.”

Through its vision of making ‘Finance for All’ a reality for its users around the world, GCash has recently become the Philippines’ first and only $5 billion unicorn. With its relentless push for financial inclusion and strong growth prospects, it recently gained new investments from Japan’s largest banking group Mitsubishi UFJ Financial Group (MUFG), and Ayala Corporation one of the Philippines’ biggest and most enduring conglomerates.

“At GCash, we prioritize finance for all Filipinos whether they are in the Philippines or abroad. We know our countrymen in Europe and the UK work hard to provide for their families back home,” says Albano. “We want to make their lives easier by looking for more convenient ways to help them send money back to their families.”

About GCash

GCash is the Philippines’ #1 Finance Super App and Largest Cashless Ecosystem. Through the GCash App, users can easily purchase prepaid airtime; pay bills via partner billers nationwide; send and receive money anywhere in the Philippines, even to other bank accounts; purchase from over 6 million partner merchants and social sellers; and get access to savings, credit, loans, insurance and invest money, and so much more, all at the convenience of their smartphones. Its mobile wallet operations are handled by G-Xchange, Inc. (GXI), a wholly-owned subsidiary of Mynt, the first and only $5 billion unicorn in the Philippines.

About Thunes:

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Thunes is the Smart Superhighway to move money around the world. Thunes’ proprietary Direct Global Network allows Members to make payments in real-time in over 130 countries and more than 80 currencies. Thunes’ Network connects directly to over 7 billion mobile wallets and bank accounts worldwide, as well as 15 billion cards via more than 320 different payment methods, such as GCash, M-Pesa, Airtel, MTN, Orange, JazzCash, Easypaisa, AliPay, WeChat Pay and many more. Thunes’ Direct Global Network differentiates itself through its worldwide reach, in-house SmartX Treasury System and Fortress Compliance Platform, ensuring Members of the Network receive unrivaled speed, control, visibility, protection, and cost efficiencies when making real-time payments, globally. Members of Thunes’ Direct Global Network include gig economy giants like Uber and Deliveroo, super-apps like Grab and WeChat, MTOs, fintechs, PSPs and banks. Headquartered in Singapore, Thunes has offices in 15 locations, including Abidjan, Barcelona, Beijing, Dubai, Hong Kong, Johannesburg, London, Manila, Nairobi, Paris, Riyadh, San Francisco, Sao Paulo and Shanghai. For more information, visit: https://www.thunes.com/

Photo – https://mma.prnewswire.com/media/2567632/GCash_x_Thunes_2.jpg

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BRIC’S Partners With BranDNA To Launch First Brick-and-Mortar Store In Mainland China.

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BEIJING, Nov. 26, 2024 /PRNewswire/ — The renowned Italian luggage maker BRIC’S in partnership with BranDNA are thrilled to announce the opening of BRIC’S first China brick-and-mortar shop in the bustling Wangfujing shopping district of Beijing. 

This strategic entry follows BRIC’S remarkable success in key Asian markets such as Japan and Korea, marking a significant milestone in its international expansion journey.

Founded in 1952, BRIC’S has become synonymous with luxury and elegance, famous for its premium leather craftsmanship and the meticulous artistry that goes into every piece of luggage, seamlessly blending tradition with innovation and function.

The newly opened BRIC’S store at Dong An Rui Jin in Beijing offers a diverse range of its signature collections, including the BELLAGIO, FIRENZE, LIFE, and X-COLLECTION tailored to discerning traveler needs. 

“We see great potential in the Chinese market, especially as travel rebounds post-pandemic,” stated Attilio Briccola, CEO of BRIC’S. “This partnership with BranDNA is pivotal in ensuring that our brand is strategically positioned for success. BranDNA’s deep industry expertise and robust network will help us present our elegant creations to a whole new audience.”  

China’s travel sector is booming, with outbound trips expected to reach 130 million this year and domestic travel up by 14.3% in the first half of 2024, per the Ministry of Culture and Tourism. This surge presents a key opportunity for BRIC’S.

James Chen, CEO of BranDNA, shared, “We are excited to satisfy the burgeoning demand of today’s travelers who seek both style and utility in their travel accessories. With BRIC’S, we aim to set a new standard in the Chinese luggage market.”

With over 20 years of brand management experience in China, BranDNA manages strong portfolio of fashion and lifestyle brands, including 7 For All Mankind, United Arrows, Pink House, BCBGMAXAZRIA, Ben Sherman, Body Glove, Borghese and many others.

Visit the new BRIC’S location at Dong An Rui Jin, Store F1-11, No. 138 Wangfujing Street, Dongcheng District, Beijing, and experience the art of Italian craftsmanship.

About BranDNA

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With a comprehensive functional service, including China entry strategy, merchandising, retail management, business development network marketing, and more, BranDNA offers a one-stop solution and a safer and efficient road for brands entering China and Southeast Asia. 

Discover more about BranDNA at www.brandna.net or connect via LinkedIn at BranDNA.

About BRIC’S

BRIC’S is a luxury Italian luggage brand known worldwide for its exceptionally designed luggage including trolleys, duffles, handbags, briefcases, and other leather and nylon goods. BRIC’S collections have always been characterized by constant development, where research and Heritage, innovation and tradition, functionality, and elegance are intertwined and balanced with skilled craft, advanced technology, and interpretation of new trends, creating a perfect fusion between shape, function, and design. Today, BRIC’S reflects timeless elegance typical of its province, Lake Como, harmoniously blending with the urban and cosmopolitan style of Milan – the city that hosts its most important Flagship Store in the Galleria Vittorio Emanuele.

For more information: www.brics.it | IG @bricsmilano | FB @bricsmilano

Photo – https://mma.prnewswire.com/media/2567616/BRIC_S_Partners_With_BranDNA_To_Launch_First_Brick_and_Mortar_Store_In.jpg

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Hinojosa obtains a new EcoVadis gold medal with a score greater than 97% of the companies evaluated

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  • The company has certified the sustainability of its business management with EcoVadis, receiving the third consecutive gold medal
  • With 78 points out of 100, Hinojosa has received its best score to date, mostly due to improvements in key areas such as environment, labour practices and human rights

VALENCIA, Spain, Nov. 26, 2024 /PRNewswire/ — Hinojosa Packaging Group has been awarded the EcoVadis gold medal for the third consecutive year, achieving with 78 points out of 100 its highest score to date and being placed in the 97th percentile of the best rated companies. The company has experienced sustained growth since has started in 2020 to certify management and positive impact on sustainability, within this internationally recognised platform.

The EcoVadis evaluation covers a wide range of non-financial management systems, including impact on issues such as environment, labour practices and human rights, ethics and sustainable procurement. Both in environmental area and labour practices & human rights’ area, the company has improved its previous scores by 10 points, reaching, respectively, 90 and 80. Progress in these two areas has enabled Hinojosa to further improve this year the overall score and position itself in the top 3% of all companies.

The improvement in the environmental area is due, among other things, to the validation of the emissions reduction targets and to achieving the Net-Zero Standard in 2050, as part of the SBTi (Science Based Target initiative). Some of the company’s commitments in this area include achieving a 60% reduction in Scope 1 and 2 emissions and a 42% reduction in Scope 3 emissions by 2030, in addition to using 100% of its electricity from renewable sources.

Adding to these commitments to the future, Hinojosa continues to work on a daily basis to ensure that its constant, steady and sustainable growth is guaranteed accordingly to circular economy’s principle. During 2023, the company reduced emissions by 16% compared to the previous year. This outstanding reduction of carbon footprint was also followed by a waste recovery rate over 95% and a 7% increase in the energy used for production from renewable sources, reaching 71% of the total energy used.

Hinojosa’s efforts to generate a positive impact in labour practices and human rights has also been recognised by EcoVadis. The expansion and consolidation of its FP Dual program or the creation of Hinojosa Cathedra together with Universitat Politècnica de València are some of the most relevant initiatives. In addition, the commitment of all company’s employees to comply with the MSH (Hinojosa Safety Model) has led to an almost fifty percent reduction in global occupational injuries.

EcoVadis corporate sustainability ratings assess each company based on its size, location and business area. More than 90,000 companies are rated internationally, receiving scores between 0 and 100 and in case their performance excels, EcoVadis will grant medals. After winning a bronze medal in 2020 and a silver medal in 2021, Hinojosa has now three consecutive gold medals in 2022, 2023 and 2024. Furthermore, thanks to this assessment, the company has received guidance on its strengths and 22 areas for improvement, which allows Hinojosa to focus on sustainability efforts and to develop action plans to improve performance.

About Hinojosa Packaging Group

Hinojosa is a leading company in the design and manufacture of sustainable packaging solutions. With more than 75 years of history, its model is based on the principles of the circular economy.

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Thanks to permanent innovation, customer orientation and the pursuit of excellence, the Group has continued to grow, experiencing a significant boost in recent years with its commitment to internationalisation. Today it has 2900 employees and 24 production plants located in Spain, Portugal, France and Italy, combining the strength of a global group with proximity to the territory.

Hinojosa’s commitment – and performance – is to generate a positive impact where it operates, contributing to a greater common well-being. Because it is not only about making the best packaging, but taking care of everything around you.

Photo: https://mma.prnewswire.com/media/2566591/Hinojosa_Packaging_Group.jpg

 

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