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PostEra announces expansion to $610M in their AI drug discovery collaboration with Pfizer

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BOSTON, Jan. 7, 2025 /PRNewswire/ — PostEra, a biotechnology company specializing in machine learning for preclinical drug discovery, today announced an expansion of their partnership with Pfizer. The parties will launch a new Antibody-Drug-Conjugate (ADC) collaboration while also expanding their existing $260M AI Lab collaboration, which itself was built upon a successful Generative Chemistry partnership.

The teams will leverage PostEra’s AI platform, Proton, a pioneering innovation in generative chemistry and synthesis-aware design, to advance several programs. These new programs include small molecule therapeutics as well as ADCs, where PostEra will use Proton to optimize properties of payloads.

PostEra will receive an upfront payment of $12M and is eligible to receive additional milestone payments and tiered royalties on any approved products arising out of the collaboration.

Over the last 3 years, as part of the AI Lab, PostEra and Pfizer scientists have partnered closely to advance several small molecule programs. After Pfizer nominated the maximum number of programs, the teams have agreed to expand the collaboration to include additional targets with PostEra receiving additional upfront payment and eligibility for milestones and royalties.

“We’re pleased to significantly expand the use of PostEra’s Proton platform. This builds on peer-reviewed publications with Pfizer validating the real-world impact of AI-driven drug discovery in hitting preclinical milestones faster than anticipated,” said Alpha Lee, Chief Scientific Officer of PostEra. “This third partnership with our long-term collaborators at Pfizer underscores Proton’s depth and strength in making a meaningful impact on real-world drug discovery campaigns,” added Aaron Morris, CEO of PostEra.

About PostEra
PostEra is building a modern 21st century biopharma. We use Proton, our AI platform for medicinal chemistry, to accelerate the discovery of new medicines for patients. PostEra is advancing an internal pipeline while also advancing small molecule programs through partnerships with biopharma. We’ve closed over $1Bn in AI partnerships including 4 multi-year agreements with Pfizer and Amgen. PostEra is also leading an antiviral drug discovery center for pandemic preparedness, funded by one of the largest grants in NIH history.

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Miami International Holdings Reports Trading Results for December and Full-Year 2024; MIAX Exchange Group Sets Multiple Volume and Market Share Records in Options and Equities Markets

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MIAMI AND PRINCETON, N.J., Jan. 8, 2025 /PRNewswire/ — Miami International Holdings, Inc. (MIH), a technology-driven leader in building and operating regulated financial markets across multiple asset classes, today reported December and full-year 2024 trading results for its U.S. exchange subsidiaries – MIAX®, MIAX Pearl®, MIAX Emerald® and MIAX SapphireTM (collectively, the MIAX Exchange Group), and MIAX FuturesTM.

December 2024 and Full-Year 2024 Trading Volume and Market Share Highlights

  • Total multi-listed options volume for the MIAX Exchange Group reached a record 1.7 billion contracts in 2024, a 6.5% increase year-over-year (YoY) and representing an annual market share of 15.1%, a 3.8% decrease YoY. December volume totaled a record 165.6 million contracts, a 29.1% increase YoY and representing a monthly market share of 16.4%, a 6.0% increase YoY.
  • MIAX Sapphire reached a volume of 65.0 million contracts in 2024, following its launch on August 12, 2024. December volume reached 18.4 million contracts, with December market share reaching 1.8%.
  • MIAX Options reached a record volume of 691.6 million contracts in 2024, a 9.1% increase YoY and representing an annual market share of 6.2%, a 1.5% decrease YoY. December volume reached 63.4 million contracts, a 23.3% increase YoY and representing a monthly market share of 6.3%, a 1.3% increase YoY.
  • MIAX Pearl Options reached a volume of 468.0 million contracts in 2024, a 27.7% decrease YoY and representing a market share of 4.2%, a 34.7% decrease YoY. December volume totaled 31.3 million contracts, a 32.5% decrease YoY and representing a monthly market share of 3.1%, a 44.5% decrease YoY.
  • MIAX Emerald reached a record volume of 465.6 million contracts in 2024, a 52.2% increase YoY and representing a record market share of 4.2%, a 37.4% increase YoY. December volume reached a record 52.5 million contracts, a 72.0% increase YoY and representing a monthly market share of 5.2%, a 41.3% increase YoY.
  • In U.S. equities, MIAX Pearl Equities™ reached a record volume of 49.9 billion shares in 2024, a 6.2% increase YoY and representing a market share of 1.6%, a 4.4% decrease YoY. December volume totaled 3.8 billion shares, a 12.8% decrease YoY and representing a market share of 1.2%, a 30.0% decrease YoY.
  • In U.S. futures, MIAX Futures, a Designated Contract Market (DCM) and Derivatives Clearing Organization (DCO), reached a record volume of 3.2 million contracts in 2024, a 10.2% increase YoY. December volume reached 197,513 contracts, a 44.5% increase YoY.

Additional MIAX Exchange Group and MIAX Futures trading volume and market share information are included in the tables below. 

Multi-Listed Options Trading Volume for

 MIAX Exchange Group, Current Month

Year-to-Date Comparison

Multi-Listed Options
Contracts

Dec-24

Dec-23

% Chg

Nov-24

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% Chg

Dec-24

Dec-23

% Chg

Trading Days

21

20

20

252

250

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U.S. Equity Options Industry

1,011,972,009

831,449,638

21.7 %

1,010,941,318

0.1 %

11,178,827,232

10,092,147,417

10.8 %

MIAX Exchange Group

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165,584,587

128,287,450

29.1 %

163,035,002

1.6 %

1,690,222,589

1,587,012,460

6.5 %

MIAX Options

63,396,610

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51,400,676

23.3 %

60,797,990

4.3 %

691,609,824

634,026,200

9.1 %

MIAX Pearl

31,298,746

46,372,764

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-32.5 %

32,006,908

-2.2 %

468,016,859

647,128,959

-27.7 %

MIAX Emerald

52,472,586

30,514,010

72.0 %

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51,730,078

1.4 %

465,577,123

305,857,301

52.2 %

MIAX Sapphire(1)

18,416,645

0. -0%

18,500,026

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-0.5 %

65,018,783

Multi-Listed Options ADV

Dec-24

Dec-23

% Chg

Nov-24

% Chg

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Dec-24

Dec-23

% Chg

U.S. Equity Options Industry

48,189,143

41,572,482

15.9 %

50,547,066

-4.7 %

44,360,426

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40,368,590

9.9 %

MIAX Exchange Group

7,884,980

6,414,373

22.9 %

8,151,750

-3.3 %

6,707,232

6,348,050

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5.7 %

MIAX Options

3,018,886

2,570,034

17.5 %

3,039,900

-0.7 %

2,744,483

2,536,105

8.2 %

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MIAX Pearl

1,490,416

2,318,638

-35.7 %

1,600,345

-6.9 %

1,857,210

2,588,516

-28.3 %

MIAX Emerald

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2,498,695

1,525,701

63.8 %

2,586,504

-3.4 %

1,847,528

1,223,429

51.0 %

MIAX Sapphire(1)

876,983

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925,001

-5.2 %

258,011

Multi-Listed Options Market Share for

MIAX Exchange Group, Current Month

Year-to-Date Comparison

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Multi-Listed Options Market
Share

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

Dec-23

% Chg

MIAX Exchange Group

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16.36 %

15.43 %

6.0 %

16.13 %

1.5 %

15.12 %

15.73 %

-3.8 %

MIAX Options

6.26 %

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6.18 %

1.3 %

6.01 %

4.2 %

6.19 %

6.28 %

-1.5 %

MIAX Pearl

3.09 %

5.58 %

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-44.5 %

3.17 %

-2.3 %

4.19 %

6.41 %

-34.7 %

MIAX Emerald

5.19 %

3.67 %

41.3 %

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5.12 %

1.3 %

4.16 %

3.03 %

37.4 %

MIAX Sapphire(1)

1.82 %

1.83 %

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-0.6 %

0.58 %

(1)

MIAX Sapphire launched trading on August 12, 2024, listing a single class for the first week and additional classes in multiple phases on a weekly schedule through the week of October 21, 2024. 

 

Equities Trading Volume for

MIAX Pearl Equities, Current Month

Year-to-Date Comparison

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Equities Shares (millions)

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

Dec-23

% Chg

Trading Days

Advertisement

21

20

20

252

250

U.S. Equities Industry

308,866

247,729

24.7 %

292,020

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5.8 %

3,064,080

2,758,344

11.1 %

MIAX Pearl Volume

3,827

4,387

-12.8 %

3,767

1.6 %

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49,865

46,935

6.2 %

MIAX Pearl ADV

182

219

-16.9 %

188

-3.3 %

198

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188

5.4 %

MIAX Pearl Market Share

1.24 %

1.77 %

-30.0 %

1.29 %

-4.0 %

1.63 %

1.70 %

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-4.4 %

Futures and Options Trading Volume and Open Interest for MIAX
Futures, Current Month

Year-to-Date Comparison

Futures & Options Contracts

Dec-24

Dec-23

% Chg

Nov-24

% Chg

Dec-24

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Dec-23

% Chg

Trading Days

21

20

20

252

250

MIAX Futures Volume

197,513

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136,652

44.5 %

342,348

-42.3 %

3,188,735

2,894,831

10.2 %

MIAX Futures ADV

9,405

6,833

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37.7 %

17,117

-45.1 %

12,654

11,579

9.3 %

MIAX Futures Open Interest

96,634

63,238

52.8 %

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82,183

17.6 %

About MIAX
MIAX’s parent holding company, Miami International Holdings, Inc., owns Miami International Securities Exchange, LLC (MIAX®), MIAX PEARL, LLC (MIAX Pearl®), MIAX Emerald, LLC (MIAX Emerald®), MIAX Sapphire LLC (MIAX SapphireTM), MIAX Futures Exchange, LLC (MIAX FuturesTM), MIAX Derivatives Exchange (MIAXdxTM), The Bermuda Stock Exchange (BSX) and Dorman Trading, LLC (Dorman Trading).

MIAX, MIAX Pearl, MIAX Emerald and MIAX Sapphire are national securities exchanges registered with the Securities and Exchange Commission that are enabled by MIAX’s in-house built, proprietary technology. MIAX offers trading of options on all four exchanges as well as cash equities through MIAX Pearl Equities™. The MIAX trading platform was built to meet the high-performance quoting demands of the U.S. options trading industry and is differentiated by throughput, latency, reliability and wire-order determinism.

MIAX Futures is a registered exchange with the Commodity Futures Trading Commission (CFTC) and offers trading in a variety of products including Hard Red Spring Wheat Futures. MIAX Futures is a Designated Contract Market (DCM) and Derivatives Clearing Organization (DCO) under the CFTC, providing DCM and DCO services in an array of asset classes.

MIAXdx is a CFTC regulated exchange and clearinghouse and is registered as a Designated Contract Market (DCM), Derivatives Clearing Organization (DCO), and Swap Execution Facility (SEF) with the CFTC.

BSX is a fully electronic, vertically integrated international securities market headquartered in Bermuda and organized in 1971. BSX specializes in the listing and trading of capital market instruments such as equities, debt issues, funds, hedge funds, derivative warrants, and insurance linked securities.

Dorman Trading is a full-service Futures Commission Merchant registered with the CFTC.

MIAX’s executive offices and National Operations Center are located in Princeton, N.J., with additional U.S. offices located in Chicago, IL and Miami, FL. MIAX Futures offices are located in Minneapolis, MN. MIAXdx offices are located in Princeton, N.J. BSX offices are located in Hamilton, Bermuda. Dorman Trading offices are located in Chicago, IL.

To learn more about MIAX visit www.miaxglobal.com.

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To learn more about MIAX Futures visit www.miaxglobal.com/miax-futures.

To learn more about MIAXdx visit www.miaxdx.com.

To learn more about BSX visit www.bsx.com.

To learn more about Dorman Trading visit www.dormantrading.com.

Disclaimer and Cautionary Note Regarding Forward-Looking Statements
The press release shall not constitute an offer to sell or a solicitation of an offer to purchase any securities of Miami International Holdings, Inc. (together with its subsidiaries, the Company), and shall not constitute an offer, solicitation or sale in any state or jurisdiction in which such offer; solicitation or sale would be unlawful. This press release may contain forward-looking statements, including forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements describe future expectations, plans, results, or strategies and are generally preceded by words such as “may,” “future,” “plan” or “planned,” “will” or “should,” “expected,” “anticipates,” “draft,” “eventually” or “projected.” You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements.

All third-party trademarks (including logos and icons) referenced by the Company remain the property of their respective owners. Unless specifically identified as such, the Company’s use of third-party trademarks does not indicate any relationship, sponsorship, or endorsement between the owners of these trademarks and the Company. Any references by the Company to third-party trademarks is to identify the corresponding third-party goods and/or services and shall be considered nominative fair use under the trademark law.

Media Contact:
Andy Nybo, SVP, Chief Communications Officer
(609) 955-2091
[email protected]

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BSV Blockchain Announces Partnership with FT Live for upcoming World Economic Forum 2025

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ZUG, Switzerland, Jan. 8, 2025 /PRNewswire/ –BSV Blockchain is partnering with the Financial Times (FT) for the upcoming World Economic Forum (WEF) conference, taking place from January 20 – 24th 2025, in Davos, Switzerland. This partnership will see BSV Blockchain and FT come together for three impactful events that explore the transformative potential of blockchain technology and its role in driving innovation and resilience across industries.

The three key events at WEF include a virtual webinar which will delve into the topic – ‘The Power of Blockchain for Business Resilience: How Shared Ledger Technologies are Redefining Efficiency and Operations,’ a Davos Daily Show which is a live stream session entitled, ‘The Critical Moment: Driving the Energy Transition Forward’ and a 75-minute roundtable discussion which will focus on the theme, ‘Leveraging Blockchain and AI for Smarter Financial Solutions.’ 

Key spokespeople from BSV Blockchain, including Aleksander Góra and Richard Baker, will attend the events in Davos. They will share their expertise to the discussions and engage with global leaders.

This partnership represents an important milestone for BSV Blockchain as it positions itself as a leading voice in blockchain and Web3 technologies. By partnering with the Financial Times and participating in the WEF 2025, BSV Blockchain aims to drive meaningful conversations about the future of enterprise blockchain and the role of blockchain in creating secure, efficient and resilient systems.

Richard Baker, Board Member at the BSV Association said, “We are very proud of this partnership with FT at WEF as it highlights shared values, drives collective progress and enhances blockchain industry trust and awareness.”

Through these events, BSV Blockchain seeks to amplify its role as an enabler in Web3 innovation and showcase the transformative potential of blockchain technology for businesses worldwide.

About BSV Blockchain:

The BSV Blockchain leads the BSV blockchain for Enterprise and Government initiatives. They are based on the original Bitcoin protocol rules and those set out in the Bitcoin white paper.

About The BSV Association:

The BSV Association is a global non-profit organisation based in Switzerland. It is focused on enhancing the adoption and development of the BSV blockchain. The BSV Association oversees the creation of tech standards and helps governments, businesses, developers, and users learn how to build a worldwide blockchain ecosystem.

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Ridgewood Infrastructure Announces Sale of SiEnergy Regulated Utility

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NEW YORK, Jan. 8, 2025 /PRNewswire/ — Ridgewood Infrastructure, a leading infrastructure investment firm focused on essential infrastructure in the U.S. lower middle market, today announced the successful sale of its 80% interest in SiEnergy to Northwest Natural Holding Company (NYSE: NWN).

SiEnergy is a regulated utility providing essential natural gas services to residential and commercial customers in the greater metropolitan areas of Houston, Dallas, and Austin. Since acquiring the business in 2019, Ridgewood Infrastructure has led the transformation of SiEnergy into one of the fastest-growing natural gas distribution utilities in the nation. Under Ridgewood’s stewardship, SiEnergy organically expanded its service base from approximately 20,000 to more than 70,000 customers.

“SiEnergy exemplifies Ridgewood Infrastructure’s continued ability to create differentiated investments on behalf of our investors,” said Michael Albrecht, Managing Partner of Ridgewood Infrastructure. “Our focus on operational and service excellence ensured the company was able to scale and will benefit SiEnergy’s customers for years to come.”

Albrecht added: “We are pleased with the accomplishments of SiEnergy, which reflect the dedication of the company’s leadership team, employees, and partners, all of whom have played a pivotal role in its success.”

RBC Capital Markets, LLC acted as exclusive financial advisor and White & Case LLP as legal advisor to Ridgewood Infrastructure.

About Ridgewood Infrastructure

Ridgewood Infrastructure is a leading infrastructure investor in the U.S. lower middle market with sectors of focus including Water, Energy Transition, Transportation, and Utilities. For more information, visit www.ridgewoodinfrastructure.com.

Contact Information:
Ridgewood Infrastructure
527 Madison Avenue, 18th Floor
New York, NY 10022
Phone: (212) 867-0050
[email protected]

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