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Cutting-Edge Cancer Therapies Lead the Way into a Transformative Year
Issued on behalf of Oncolytics Biotech Inc.
USA News Group News Commentary
VANCOUVER, BC, Jan. 15, 2025 /PRNewswire/ — As 2025 begins, the American Association for Cancer Research (AACR) recently published forecasts from experts showcasing transformative advances in cancer research, including cutting-edge AI technologies, novel targeted therapies, and innovative cancer vaccines. With over 50 oncology drug approvals in 2024, including the first tumor-infiltrating lymphocyte cell therapy, this year holds great promise for precision medicine and immunotherapy. Amid growing expectations for an active year for biotech stocks in 2025, developers of new cancer therapies are already releasing important developments, with recent news coming from Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Adaptive Biotechnologies Corporation (NASDAQ: ADPT), NeoGenomics, Inc. (NASDAQ: NEO), Elevation Oncology, Inc. (NASDAQ: ELEV), and ORIC Pharmaceuticals, Inc. (NASDAQ: ORIC).
The article continued: Statista analysts project that the oncology drugs market will generate an estimated revenue of $208.9 billion in 2025. Meanwhile, Global Market Insights reports that the global oncology market, valued at approximately $320.3 billion in 2024, is expected to grow at a compound annual growth rate (CAGR) of 10.8% from 2025 to 2034, reaching $866.1 billion.
Regulatory Approval Clears Path for Oncolytics Biotech® to Advance Promising Pancreatic Cancer Treatment, Following a Review of Safety Data
Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), a leading clinical-stage company specializing in immunotherapy for oncology, today announced that Germany’s medical regulatory body, the Paul-Ehrlich-Institute (PEI), has approved the continuation of patient enrollment into Cohort 5 of the GOBLET study. This cohort is evaluating pelareorep in combination with modified FOLFIRINOX (mFOLFIRINOX) with or without atezolizumab (Tecentriq®) in newly diagnosed pancreatic ductal adenocarcinoma (PDAC) patients.
Following a positive safety review by the independent Data Safety Monitoring Board (DSMB), which recommended continuation, the PEI’s approval allows Cohort 5 to progress to full enrollment. Early safety data will be presented at the upcoming 2025 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium later this month, with initial efficacy results expected in the second half of the year.
“Pelareorep has the potential to meaningfully improve outcomes for patients with metastatic pancreatic cancer,” said Thomas Heineman, M.D., Ph.D., Chief Medical Officer for Oncolytics Biotech. “Encouraging tumor response rates observed in an earlier cohort of the GOBLET study underscore pelareorep’s promise in this disease. GOBLET Cohort 5 extends our evaluation by testing pelareorep with a different chemotherapy regimen, mFOLFIRINOX, which broadens the range of pancreatic cancer patients who may benefit from this innovative therapy. Positive results from this cohort may ultimately enable pelareorep to benefit the large majority of metastatic pancreatic patients for whom improved treatment options are badly needed.”
The Phase 1/2 GOBLET study is testing pelareorep, an oncolytic reovirus, in combination with other treatments for advanced gastrointestinal cancers, including pancreatic, colorectal, and anal cancers. Conducted at 17 centers in Germany, the study aims to evaluate response rates, safety, and biomarkers across multiple treatment arms, with promising cohorts advancing to further testing.
AIO is a non-profit organization that evolved from the medical oncology working group within the German Cancer Society (DKG). Dedicated to advancing science and research in medical oncology, AIO has grown into a prominent sponsor and study management company. Over the years, it has established a strong reputation both within Germany and on the international stage for its contributions to oncology research and study development.
Oncolytics Biotech’s work represents a significant step forward in the fight against metastatic pancreatic cancer, addressing a critical need for more effective treatment options in this aggressive disease. By leveraging the innovative potential of pelareorep in combination with established therapies, the company is paving the way for breakthroughs that could transform outcomes for patients and unlock value for investors.
CONTINUED… Read this and more news for Oncolytics Biotech at: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/
In other recent industry developments and happenings in the market include:
Adaptive Biotechnologies Corporation (NASDAQ: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, NeoGenomics, Inc. (NASDAQ: NEO), a leading oncology testing services company, recently announced a multi-year exclusive strategic commercial collaboration that will advance minimal residual disease (MRD) monitoring options for patients with select blood cancers.
Adaptive’s clonoSEQ® is the first and only FDA-cleared test for detecting minimal residual disease (MRD) in lymphoid cancers, while NeoGenomics’ COMPASS® and CHART® offer comprehensive and personalized testing for complex blood cancers. By combining clonoSEQ with these advanced services, oncologists can develop tailored treatment plans, assess patient risk more accurately, and gain real-time insights into disease progression, enhancing care for blood cancer patients.
“As a leader in oncology testing with an extensive menu of precision oncology offerings, NeoGenomics is a natural partner for us,” said Chad Robins, CEO and Co-Founder of Adaptive Biotechnologies. “We are proud of this collaboration, which expands access to the valuable insights that clonoSEQ MRD results offer, ultimately helping more providers and patients benefit from knowing their MRD status.”
Under a new agreement, clinicians using NeoGenomics’ COMPASS diagnostic tool for blood cancers like multiple myeloma, B-ALL, CLL, and DLBCL can now include Adaptive Biotechnologies‘ clonoSEQ Clonality (ID) test at diagnosis to identify patient-specific DNA sequences for ongoing MRD (minimal residual disease) tracking. This integration allows seamless monitoring of disease burden throughout treatment using CHART, giving patients access to clonoSEQ insights and increasing eligibility for clinical trials that rely on MRD testing to guide therapy decisions. All clonoSEQ testing will be conducted at Adaptive’s specialized laboratory, ensuring accurate and consistent results.
Adaptive and NeoGenomics are preparing to implement the infrastructure for their partnership, with cross-promotional efforts expected to launch later this year, though financial terms remain undisclosed.
iBio, Inc. (NYSE-American: IBIO) an AI-driven innovator of precision antibody immunotherapies, in collaboration with AstralBio Inc., recently announced they’ve developed a breakthrough antibody targeting Activin E, a key protein linked to cardiometabolic disorders and obesity. This achievement demonstrates the strength of iBio’s platform in tackling challenging targets and advancing innovative therapies, with plans for rapid testing of this and other candidates in advanced disease models.
“Developing a functional antibody against Activin E, an achievement we believe to be an industry first, is a significant milestone for iBio,” said Martin Brenner, Ph.D., DVM, iCEO and Chief Scientific Officer of iBio. “This breakthrough strengthens our efforts to expand our therapeutics pipeline for the treatment of cardiometabolic disorders and obesity with innovative next-generation solutions.”
Elevation Oncology, Inc. (NASDAQ: ELEV), an innovative oncology company focused on the discovery and development of selective cancer therapies to treat patients across a range of solid tumors with significant unmet medical needs, recently announced program updates and upcoming milestones.
The company is advancing its pipeline with EO-3021, a potentially best-in-class antibody drug conjugate targeting Claudin 18.2 in advanced gastric/GEJ cancer, showing promising early results with a 42.8% overall response rate and a differentiated safety profile. The ongoing Phase 1 trial includes monotherapy and combination studies, with additional data expected in 2025 and 2026, while EO-1022, a HER3-targeting ADC for solid tumors, is progressing toward preclinical data release in 2025 and an IND filing in 2026.
“We are rapidly advancing EO-3021 to address significant unmet needs in treating earlier lines of advanced gastric/GEJ cancer, where we believe we have a unique ability to improve on the standard of care,” said Joseph Ferra, President and CEO of Elevation Oncology. “As we enter 2025, we are honing our focus, leveraging the competitive anti-tumor activity and differentiated safety profile of EO-3021 to explore combination approaches in the first- and second-line settings.”
ORIC Pharmaceuticals, Inc. (NASDAQ: ORIC), a clinical stage oncology company focused on developing treatments that address mechanisms of therapeutic resistance, recently provided early Phase 1b combination data for ORIC-944, operational highlights for 2024, and anticipated upcoming milestones.
ORIC-944, a potent PRC2 inhibitor, has shown strong potential in treating metastatic castration-resistant prostate cancer (mCRPC), with deep and durable PSA responses and a favorable safety profile in early Phase 1b combination trials with apalutamide and darolutamide. Alongside advancements in ORIC-114 for NSCLC, ORIC’s 2024 milestones include promising clinical data, strategic collaborations with Johnson & Johnson and Bayer, and a robust cash position expected to support operations into late 2026, positioning the company for continued progress in oncology drug development.
“We made strong progress on multiple fronts in 2024, most notably with the initiation of multiple cohorts for ORIC-114 in NSCLC and ORIC-944 in mCRPC,” said Jacob M. Chacko, M.D., President and CEO of Oric. “We also forged three strategic collaborations with leading pharma partners, strengthened our leadership team to expand functional capabilities, and completed a $125 million PIPE financing, extending our cash runway into late 2026. These accomplishments position us well for 2025 and beyond, with seven anticipated data readouts over the next 18 months as we advance toward potentially initiating registrational studies for ORIC-114 in the second half of 2025 and for ORIC-944 in early 2026.”
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USA NEWS GROUP
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View original content:https://www.prnewswire.co.uk/news-releases/cutting-edge-cancer-therapies-lead-the-way-into-a-transformative-year-302351959.html
BEIJING, March 17, 2025 /PRNewswire/ — This is a report from China.org.cn:
The 2025 Global Digital Economy Conference (GDEC)’s International Cooperation Forum series was held in Barcelona, Spain, on March 4.
Themed “Integration, Innovation, Win-Win: Co-creating a New Blueprint for the China-Europe Digital Economy,” the Digital Economy Cooperation Forum was hosted by the GDEC Organizing Committee, and organized by the Beijing Municipal Bureau of Economy and Information Technology (BMBEIT).
The event attracted more than 150 government representatives, corporate executives, industry association leaders from China, Spain and other European countries, and more than 60 overseas companies and institutions participated in it.
Jiang Guangzhi, the BMBEIT chief, delivered an opening speech in the form of digital human. In his address, Jiang said that the capital city of China, as a pioneer in the global digital economy, actively implements the national digital economy development strategy, and Barcelona, as the core hub of the European digital economy, has obvious advantages in science and technology industry clusters. The two cities have broad prospects for cooperation in the field of digital economy.
On the sidelines of the forum, BMBEIT also held a business and investment promotion activity called “Night of Beijing” in the Spanish city.
Relevant persons in charge of the BMBEIT promoted Beijing’s leading digital technology solutions in key digital economy industries such as autonomous driving, smart logistics, smart home, digital healthcare, and value-added telecommunications, combining core technologies, application scenarios, international promotion, and effectiveness cases.
Additionally, Lu Yiji, Chairman of the China-Europe Digital Association, Ignasi Castelló, Chief Purchasing Officer of FICOSA International Spain, Li Kang, Senior Vice President of China Telecom International, and Zhang Genxue, General Manager of Beijing Digital Economy Enterprises Overseas Innovation Service Base, each presented the current state and trends of digital economy development from different perspectives, providing valuable experiences and insights for enterprises and institutions.
The GDEC has been successfully held for four sessions since 2021. It is committed to promoting more comprehensive international cooperation in the digital economy industry and promoting the friendly and sustainable development of the global digital ecology. The 2025 GDEC will be held in Beijing in July.
Digital economy focus of China-EU cooperation: forum
http://www.china.org.cn/business/2025-03/06/content_117750616.htm
View original content:https://www.prnewswire.co.uk/news-releases/digital-economy-focus-of-china-eu-cooperation-forum-302402825.html
MEKKA integrates behavioural finance and market intelligence to transform investment decision-making
DUBAI, UAE, March 17, 2025 /PRNewswire/ — Fayafi Investment Holding, the first UAE firm made available through a bankable certificate issued under the SIX Swiss Exchange framework and featured on Bloomberg, has unveiled the proprietary algorithm MEKKA underpinning its investment decision-making.
MEKKA, an acronym for Market Emotional Knowledge & Kinetic Analysis, was created by Fayafi Investment Holding’s Executive President Dr Patrick Pilati in 2017 in collaboration with Swiss mathematicians.
The advanced financial platform recognizes that markets are driven by human emotions, biases, and psychological patterns. MEKKA integrates sentiment analysis, AI-driven market forecasting, and real-time behavioural insights to optimize investment strategies.
MEKKA relies on Market Emotional Knowledge (MEK) to understand and quantify investor sentiment, cognitive biases, and emotional market drivers. It also uses Kinetic Analysis (KA) to study market momentum driven by behavioural patterns, liquidity flows and investor reactions. MEKKA helps institutional investors like Fayafi anticipate market shifts before they occur.
“While traditional financial models focus purely on quantitative and fundamental analysis, MEKKA combines psychology, AI, and trading analytics to deliver a more complete understanding of market behaviour. By integrating market sentiment analysis, AI-driven behavioural finance models, and predictive trading intelligence, MEKKA enables a more complete understanding of market sentiment. It allows investors to identify opportunities before they gain mainstream attention,” said Dr. Patrick Pilati, Executive President of Fayafi Investment Holding.
MEKKA continuously scans and quantifies investor sentiment using AI-powered real-time monitoring of news and social media analysis to detect sentiment and market shifts. It tracks proprietary indicators measuring emotional states in equity, commodity, and bond markets. It also offers decision-makers investor sentiment heatmaps, visually depicting emotional trends across global financial markets. These insights enable investors to detect early signs of market movements.
“MEKKA represents a transformational shift in financial markets, proving that investor psychology is as crucial as technical and fundamental analysis. MEKKA empowers investors to understand hidden psychological market drivers, capitalise on market inefficiencies and mitigate risk through behavioural-based trading strategies. With MEKKA, investment decisions are no longer based solely on numbers but are also guided by deep insights into human psychology and market emotion,” he added.
MEKKA offers deep insights into niche strategic investments such as isotope copper — of which Fayafi holds USD 3.6 billion in reserves within its Dubai vaults at Ferrari Logistics DMCC. Fayafi Investment SPV has succeeded in commoditizing and securitizing isotope copper, making available USD 1.44B in Euroclear security certificates backed by the metal on the SIX Swiss Exchange in February 2025.
In 2025, Fayafi Investment Holding Limited integrated MEKKA into its investment framework, enhancing its ability to navigate market trends, manage risks and capitalize on behavioural-driven opportunities. MEKKA has enabled Fayafi to optimise its investment decisions by aligning commodity investments with sentiment-based market trends, and enhance liquidity management by timing transactions based on emotional flow predictions.
Backed by Fayafi Investment Holding, MEKKA is evolving rapidly. Upcoming milestones include the launch of automated financial advisors powered by MEKKA’s reasoning engine, integration with blockchain and DeFi, and expanding MEKKA’s insights beyond commodities into other sectors including real estate, venture capital and private equity markets. A key goal, according to Dr Pilati, is to begin offering MEKKA’s capabilities to investment banks and sovereign wealth funds as a licensed platform.
“MEKKA has enabled Fayafi to achieve stronger market positioning, mitigate risks, and maximize returns by aligning investments with psychological market trends. With its rapid improvements and new features, MEKKA is set to reshape the future of behavioural finance-driven investing while keeping Fayafi Investment Holding Limited at the forefront of global financial market intelligence,” Dr Pilati concluded.
Contact Details:
FAYAFI Investment Holding
[email protected]
DIFC, Dubai, UAE
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Fintech PR
Term Structure Institutional (TSI): The Future of Institutional Fixed-Rate Digital Asset Lending and Borrowing
HONG KONG, March 17, 2025 /PRNewswire/ —
As institutional adoption of digital assets accelerates, the demand for reliable, predictable, and efficient lending and borrowing solutions has never been greater. Term Structure Institutional (TSI) is at the forefront of this transformation, offering a cutting-edge fixed-rate borrowing and lending platform designed to meet the needs of institutional investors.
With a robust foundation built on Fireblocks’ industry-leading Multi-Party Computation (MPC) technology and as an advanced Electronic Communication Network (ECN), TSI eliminates the risks of volatile lending and borrowing markets, providing institutions with seamless access to fixed-income opportunities in the digital asset space.
Despite the rapid growth of digital asset markets, institutional participants continue to face significant barriers:
- Unpredictable Borrowing Costs – Open-term loans expose institutions to fluctuating interest rates, making financial planning challenging.
- Security Concerns – The on-chain DeFi ecosystem is prone to hacks and vulnerabilities, deterring institutional involvement.
- Limited Trading Flexibility – Traditional custodian solutions often restrict institutions from executing sophisticated borrowing and lending strategies.
- Inefficiencies in OTC Markets – A lack of transparency and standardized pricing leads to suboptimal execution.
TSI directly addresses these pain points, delivering a reliable and efficient fixed-income platform purpose-built for institutional engagement.
Enhanced Security with Fireblocks MPC Technology
TSI integrates Fireblocks’ cutting-edge MPC technology, ensuring that institutional assets remain protected at all times. By eliminating single points of failure, TSI significantly enhances risk management and compliance.
Predictable, Fixed-Rate & Fixed-Term Borrowing & Lending
TSI enables institutions to lock in stable interest rates and predefined loan durations, providing much-needed certainty for long-term financial strategies.
Efficient Market Access
TSI’s ECN-powered platform revolutionizes price discovery and liquidity aggregation, bringing the standardization and efficiency of traditional finance into the digital asset ecosystem.
Institutional-Grade Over-Collateralized Lending
To mitigate default risks, TSI requires borrowers to provide collateral exceeding the loan value, ensuring robust lender protection and market stability.
Streamlined Collateral Liquidation
TSI’s structured liquidation process ensures collateral is efficiently managed, safeguarding institutional participants from unnecessary losses.
TSI is more than just a platform—it’s a game-changer for institutional digital asset lending and borrowing. By combining enhanced security and fixed-rate certainty, TSI is setting a new standard for institutional finance in the digital asset space.
Are you ready to experience the next evolution of institutional digital asset lending? Join TSI today and unlock the power of predictable, reliable, and institutional-grade financing. Follow us on X to stay updated!
Term Structure Labs Limited is a company registered in BVI, primarily focused on DeFi research with an emphasis on fixed-rate solutions. Term Structure Institutional (TSI) is one of its products, designed specifically to cater to institutional users, offering tailored solutions within the broader Term Structure ecosystem.
View original content:https://www.prnewswire.co.uk/news-releases/term-structure-institutional-tsi-the-future-of-institutional-fixed-rate-digital-asset-lending-and-borrowing-302401796.html
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