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Quoin Pharmaceuticals: On Track to Deliver the First FDA-Approved Treatment for Netherton Syndrome

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Quoin Pharmaceuticals (QNRX) is developing a potential treatment for a patient population in desperate need. We spoke with CEO, Dr. Michael Myers, to find out more about Netherton Syndrome, a rare and devastating genetic disease.

New York, New York–(Newsfile Corp. – May 17, 2022) – PCG Digital — People with rare diseases face severe limitations, debilitating discomfort, and a very uncertain future. Children are especially vulnerable:

Rare diseases are only rare if you don’t live with one
 
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Specialty pharmaceutical company, Quoin Pharmaceuticals (NASDAQ: QNRX), is relentlessly pursuing the development of therapeutic products for rare and orphan diseases. Quoin’s lead product is a potential treatment for Netherton syndrome, a rare and devastating genetic disease that affects the skin, hair, and immune system.

Symptomatic within the first weeks of life, the 1 in 200,000 newborns who are born with the disease experience a lifetime of illness and an enhanced susceptibility to infections, allergies, skin cancer, severe pruritus and other diseases. It is believed that about 6,000-7,000 people in Europe and the US combined suffer from Netherton syndrome. The disease requires lifelong management, with current treatments providing only limited symptomatic relief.

Quoin is now potentially on track to deliver the first FDA approved treatment for this devastating disease. The company’s lead candidate, QRX003, is a whole-body, whole life topical treatment that is providing hope to those around the globe suffering from Netherton syndrome.

We spoke with Dr. Michael Myers, co-founder and CEO of Quoin, to find out more about this disease and what drives him to find an effective treatment.

Q. Netherton syndrome is a skin disease that causes dryness and shedding. Is it similar to eczema or psoriasis?

A. Netherton syndrome is most definitely not a skin disorder. It is a debilitating genetic disease. People with Netherton syndrome have too few layers of skin, so the skin cannot perform its primary protective function. It is a devastating disease for patients and their families, requiring lifelong management of painful, scaly, and itchy skin with an increased risk of severe dehydration, infection, allergies and skin cancer.

Q. What have you heard from people with Netherton syndrome?

A. We hear a mix of frustration, desperation, and devastation. Just last week we received an email from parents of a one-month-old baby with NS. She has to be kept in an incubator at 60% humidity because of how severe her dehydration is, and it’s unlikely she will survive. Two years ago, the parents lost another child with NS at just nine days old. They are desperate for any sort of treatment that might help.

A dermatologist reached out to us regarding a patient, a woman in her 30s with NS who has struggled terribly her whole life. She’s hoping her patient can be involved in our clinical study to give her a chance at living a normal life.

Recently, a father in Germany contacted us because he has a five-year-old daughter with NS who is very ill. He too is hoping his daughter can participate in our clinical study.

Every time we are contacted like this by a parent or a caregiver, it reinforces our determination to progress the development of this product as expeditiously as possible.

Q. What are the current treatments? Can you tell us more about QRX003?

A. There are no approved therapies for Netherton syndrome and current treatment options offer limited benefits, primarily minor symptomatic relief. And even with these treatments, care has to be taken. Emollient moisturizers containing lanolin or petroleum can damage the fragile skin of people with NS because of the friction caused by application and removal. Topical steroids may reduce skin thickness by 70%. Because of their defective skin barrier, people with NS can also develop dangerously high blood levels of the ingredients used in topical treatments. QRX003 is a unique product that targets the cause of the excess shedding that leads to the highly porous skin that Netherton patients have. In addition, if approved, QRX003 may be used on the entire body surface daily to provide a barrier over the skin, limiting the penetration of unwanted environmental agents whilst enabling the architecture of the skin to heal.

Q. When might people with NS be able to use QRX003?

A. Our goal is to obtain the necessary approvals to make our products available to as many people as we can, as quickly as possible. Quoin has received Investigational New Drug clearance from the FDA for QRX003 and will initiate clinical testing in patients in 2Q of 2022. In addition to our planned commercial infrastructure for the US and Europe, we have distribution agreements for QRX003 in almost 60 countries. Many of these regions have early-access programs that could potentially allow QRX003 to be prescribed on a named-patient basis before formal regulatory approval.

Q. What motivates you to work on treatments such as QRX003?

A. People living with Netherton syndrome have been neglected for a long time, waiting and waiting for an effective treatment. The pursuit of unique solutions for rare and orphan diseases has been Quoin’s mission right from the very start. Both my co-founder, Denise, and I have seen the impact Netherton syndrome has on patients and their families – and not just physically. There is a heavy emotional price to pay. We at Quoin are 100% dedicated to supporting these underserved people and doing everything we can to develop effective solutions to treat rare diseases that currently have no treatment or cure.

Disclaimer

This communication was produced by PCG Digital Holdings, LLC, an affiliate of PCG Advisory Inc., (together “PCG”). PCG is not a registered or licensed broker-dealer nor investment adviser. No information contained in this communication constitutes an offer to sell, a solicitation of an offer to buy, or a recommendation of any security. PCG may be compensated by respective clients for publicizing information relating to its client’s securities. See www.pcgadvisory.com/disclosures.

PCG Digital
[email protected]
646-863-6341

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Fintech

How to identify authenticity in crypto influencer channels

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Modern brands stake on influencer marketing, with 76% of users making a purchase after seeing a product on social media.The cryptocurrency industry is no exception to this trend. However, promoting crypto products through influencer marketing can be particularly challenging. Crypto influencers pose a significant risk to a brand’s reputation and ROI due to rampant scams. Approximately 80% of channels provide fake statistics, including followers counts and engagement metrics. Additionally, this niche is characterized by high CPMs, which can increase the risk of financial loss for brands.

In this article Nadia Bubennnikova, Head of agency Famesters, will explore the most important things to look for in crypto channels to find the perfect match for influencer marketing collaborations.

 

  1. Comments 

There are several levels related to this point.

 

LEVEL 1

Analyze approximately 10 of the channel’s latest videos, looking through the comments to ensure they are not purchased from dubious sources. For example, such comments as “Yes sir, great video!”; “Thanks!”; “Love you man!”; “Quality content”, and others most certainly are bot-generated and should be avoided.

Just to compare: 

LEVEL 2

Don’t rush to conclude that you’ve discovered the perfect crypto channel just because you’ve come across some logical comments that align with the video’s topic. This may seem controversial, but it’s important to dive deeper. When you encounter a channel with logical comments, ensure that they are unique and not duplicated under the description box. Some creators are smarter than just buying comments from the first link that Google shows you when you search “buy YouTube comments”. They generate topics, provide multiple examples, or upload lists of examples, all produced by AI. You can either manually review the comments or use a script to parse all the YouTube comments into an Excel file. Then, add a formula to highlight any duplicates.

LEVEL 3

It is also a must to check the names of the profiles that leave the comments: most of the bot-generated comments are easy to track: they will all have the usernames made of random symbols and numbers, random first and last name combinations, “Habibi”, etc. No profile pictures on all comments is also a red flag.

 

LEVEL 4

Another important factor to consider when assessing comment authenticity is the posting date. If all the comments were posted on the same day, it’s likely that the traffic was purchased.

 

2. Average views number per video

This is indeed one of the key metrics to consider when selecting an influencer for collaboration, regardless of the product type. What specific factors should we focus on?

First & foremost: the views dynamics on the channel. The most desirable type of YouTube channel in terms of views is one that maintains stable viewership across all of its videos. This stability serves as proof of an active and loyal audience genuinely interested in the creator’s content, unlike channels where views vary significantly from one video to another.

Many unauthentic crypto channels not only buy YouTube comments but also invest in increasing video views to create the impression of stability. So, what exactly should we look at in terms of views? Firstly, calculate the average number of views based on the ten latest videos. Then, compare this figure to the views of the most recent videos posted within the past week. If you notice that these new videos have nearly the same number of views as those posted a month or two ago, it’s a clear red flag. Typically, a YouTube channel experiences lower views on new videos, with the number increasing organically each day as the audience engages with the content. If you see a video posted just three days ago already garnering 30k views, matching the total views of older videos, it’s a sign of fraudulent traffic purchased to create the illusion of view stability.

 

3. Influencer’s channel statistics

The primary statistics of interest are region and demographic split, and sometimes the device types of the viewers.

LEVEL 1

When reviewing the shared statistics, the first step is to request a video screencast instead of a simple screenshot. This is because it takes more time to organically edit a video than a screenshot, making it harder to manipulate the statistics. If the creator refuses, step two (if only screenshots are provided) is to download them and check the file’s properties on your computer. Look for details such as whether it was created with Adobe Photoshop or the color profile, typically Adobe RGB, to determine if the screenshot has been edited.

LEVEL 2

After confirming the authenticity of the stats screenshot, it’s crucial to analyze the data. For instance, if you’re examining a channel conducted in Spanish with all videos filmed in the same language, it would raise concerns to find a significant audience from countries like India or Turkey. This discrepancy, where the audience doesn’t align with regions known for speaking the language, is a red flag.

If we’re considering an English-language crypto channel, it typically suggests an international audience, as English’s global use for quality educational content on niche topics like crypto. However, certain considerations apply. For instance, if an English-speaking channel shows a significant percentage of Polish viewers (15% to 30%) without any mention of the Polish language, it could indicate fake followers and views. However, if the channel’s creator is Polish, occasionally posts videos in Polish alongside English, and receives Polish comments, it’s important not to rush to conclusions.

Example of statistics

 

Wrapping up

These are the main factors to consider when selecting an influencer to promote your crypto product. Once you’ve launched the campaign, there are also some markers to show which creators did bring the authentic traffic and which used some tools to create the illusion of an active and engaged audience. While this may seem obvious, it’s still worth mentioning. After the video is posted, allow 5-7 days for it to accumulate a basic number of views, then check performance metrics such as views, clicks, click-through rate (CTR), signups, and conversion rate (CR) from clicks to signups.

If you overlooked some red flags when selecting crypto channels for your launch, you might find the following outcomes: channels with high views numbers and high CTRs, demonstrating the real interest of the audience, yet with remarkably low conversion rates. In the worst-case scenario, you might witness thousands of clicks resulting in zero to just a few signups. While this might suggest technical issues in other industries, in crypto campaigns it indicates that the creator engaged in the campaign not only bought fake views and comments but also link clicks. And this happens more often than you may realize.

Summing up, choosing the right crypto creator to promote your product is indeed a tricky job that requires a lot of resources to be put into the search process. 

Author Nadia Bubennikova, Head of agency  at Famesters

Author

Nadia Bubennikova, Head of agency at Famesters

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Fintech

Central banks and the FinTech sector unite to change global payments space

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The BIS, along with seven leading central banks and a cohort of private financial firms, has embarked on an ambitious venture known as Project Agorá.

Named after the Greek word for “marketplace,” this initiative stands at the forefront of exploring the potential of tokenisation to significantly enhance the operational efficiency of the monetary system worldwide.

Central to this pioneering project are the Bank of France (on behalf of the Eurosystem), the Bank of Japan, the Bank of Korea, the Bank of Mexico, the Swiss National Bank, the Bank of England, and the Federal Reserve Bank of New York. These institutions have joined forces under the banner of Project Agorá, in partnership with an extensive assembly of private financial entities convened by the Institute of International Finance (IIF).

At the heart of Project Agorá is the pursuit of integrating tokenised commercial bank deposits with tokenised wholesale central bank money within a unified, public-private programmable financial platform. By harnessing the advanced capabilities of smart contracts and programmability, the project aspires to unlock new transactional possibilities that were previously infeasible or impractical, thereby fostering novel opportunities that could benefit businesses and consumers alike.

The collaborative effort seeks to address and surmount a variety of structural inefficiencies that currently plague cross-border payments. These challenges include disparate legal, regulatory, and technical standards; varying operating hours and time zones; and the heightened complexity associated with conducting financial integrity checks (such as anti-money laundering and customer verification procedures), which are often redundantly executed across multiple stages of a single transaction due to the involvement of several intermediaries.

As a beacon of experimental and exploratory projects, the BIS Innovation Hub is committed to delivering public goods to the global central banking community through initiatives like Project Agorá. In line with this mission, the BIS will soon issue a call for expressions of interest from private financial institutions eager to contribute to this ground-breaking project. The IIF will facilitate the involvement of private sector participants, extending an invitation to regulated financial institutions representing each of the seven aforementioned currencies to partake in this transformative endeavour.

Source: fintech.globa

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TD Bank inks multi-year strategic partnership with Google Cloud

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TD Bank has inked a multi-year deal with Google Cloud as it looks to streamline the development and deployment of new products and services.

The deal will see the Canadian banking group integrate the vendor’s cloud services into a wider portion of its technology solutions portfolio, a move which TD expects will enable it “to respond quickly to changing customer expectations by rolling out new features, updates, or entirely new financial products at an accelerated pace”.

This marks an expansion of the already established relationship between TD Bank and Google Cloud after the group previously adopted the vendor’s Google Kubernetes Engine (GKE) for TD Securities Automated Trading (TDSAT), the Chicago-based subsidiary of its investment banking unit, TD Securities.

TDSAT uses GKE for process automation and quantitative modelling across fixed income markets, resulting in the development of a “data-driven research platform” capable of processing large research workloads in trading.

Dan Bosman, SVP and CIO of TD Securities, claims the infrastructure has so far supported TDSAT with “compute-intensive quantitative analysis” while expanding the subsidiary’s “trading volumes and portfolio size”.

TD’s new partnership with Google Cloud will see the group attempt to replicate the same level of success across its entire portfolio.

Source: fintechfutures.com

The post TD Bank inks multi-year strategic partnership with Google Cloud appeared first on HIPTHER Alerts.

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