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Invitae to Acquire Jungla to Advance Genetic Variant Interpretation, Adds Supplemental RNA Analysis to Deliver Deeper, More Informative Results to Patients

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Invitae Corporation (NYSE: NVTA), a leading medical genetics company, today announced it has entered into a definitive agreement to acquire Jungla Inc., a privately held company funded by Andreessen Horowitz (a16z) that has developed a cloud-based platform that combines clinical knowledge with advances in functional genomics, biophysics, cellular engineering, machine learning, and distributed systems to help clinicians and patients understand the results of genetic and genomic tests. The combination is expected to further enhance Invitae’s genetic variant interpretation and ability to deliver high-quality, more affordable genetic testing for use in mainstream medical care. Separately, Invitae announced the addition of RNA analysis to its commercial testing, beginning with patients undergoing cancer testing.

“Interpreting the genetic variants observed during sequencing is what turns genetic data into decision-making power for patients and clinicians. Bringing Jungla’s technologies onto our platform will help us provide support to our patients in a scalable way,” said Sean George, co-founder and chief executive officer of Invitae. “Whether incorporating computational and experimental approaches for protein analysis or adding RNA analysis to augment variant interpretation, we lead the molecular genetic testing industry in leveraging advanced clinical genetic variant interpretation technologies that enable us to provide patients and clinicians with genetic information to inform healthcare decisions.”

Large-Scale Molecular and Genomic Technologies to Enhance Variant Interpretation

Jungla’s Functional Modeling Platform (FMP) is an active machine learning engine that enhances clinical knowledge by continuously integrating functional, structural and computational data into auditable and accurate predictive models for clinical variant interpretation. The technology delivers performance that exceeds recommendations from the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) across hundreds of genes and conditions.

Jungla’s technology can augment Invitae’s ability to understand the impact of variants on molecular function, be they protein or RNA molecules, through the application of advanced methods in functional genomics, structural biology and biophysics. This technology, coupled with Invitae’s exacting, logical and reproducible approach for variant classification and interpretation, Sherloc, can help Invitae deliver more informative results to patients.

In November 2018, Invitae and Jungla successfully completed a four-month pilot study of the performance of Jungla’s proprietary technologies in predicting the clinical relevance of differences in human DNA sequence (variants) found in individuals undergoing testing for hereditary disease. The results demonstrated that support from Jungla’s FMP can markedly increase the molecular understanding of variants while maintaining the high accuracy of Invitae’s classifications, thereby significantly increasing the efficiency of interpretation and scalability of genetic testing with enhanced quality of test results. In addition, the prospective integration of Invitae’s knowledge-base and Jungla’s technologies is expected to optimize clinical guidance, leveraging the data from each patient to improve results for the next. The results show that Jungla’s technologies can clarify the interpretation of variants, moving them from the uncertain category to pathogenic or benign status.

“At Jungla, we are continuously applying and combining advances in molecular, cellular, and computational technologies to the complex work of genetic variant interpretation with the goal of making it easier to conduct the highest quality genetic interpretation at scale,” said Carlos Araya, co-founder and chief executive officer of Jungla. “Our team has been at the forefront of technologies to accelerate the understanding of variants for nearly a decade. Combining our learning engine with Invitae’s rigorous interpretation framework will extend the reach of our technology and help more patients and clinicians get the information they need.”

Under the definitive agreement, Invitae will acquire Jungla for approximately $50 million upon closing, $35 million of which shall be in Invitae common stock and $15 million of which shall be in cash, subject to certain adjustments. In addition, Invitae will pay up to $15 million upon the achievement of certain milestones, mostly in stock with the balance in cash. The acquisition is expected to close in the coming days, subject to customary closing conditions. Invitae has already factored in the additional operating expense of this acquisition in prior statements about expected 2019 cash burn.

Supplemental RNA Analysis Further Deepens Variant Classification in Cancer Testing

While most gene changes associated with a hereditary disease have their effect by directly altering the function of the protein that is specified by that gene, a small fraction of gene changes are known to alter the way messenger RNAs (mRNAs), the blueprints for proteins, are made in the body. A growing area of research has focused on using RNA analysis to help resolve variants of uncertain significance (VUS), particularly those VUS that are predicted to affect mRNA creation, also known as RNA splicing. In order to contribute to this research and further reduce the uncertainty inherent in genetic testing results, Invitae has added supplemental RNA testing for VUS that are predicted to affect RNA splicing and have been identified in a gene from any of our hereditary cancer panels.

Invitae’s approach to supplemental RNA analysis, RNA-seq, includes both qualitative (evaluation of abnormal mRNAs) and quantitative (the amount of mRNAs) results, which ultimately provides deeper insight into the variant-disease relationship compared to the use of qualitative results alone.

“The addition of RNA analysis to our variant classification pipeline provides another tool to reduce the number of variants that cannot be confidently classified based on DNA sequencing alone,” said Robert Nussbaum, chief medical officer of Invitae. “By applying this technology first to those cancer genes and variants where it is most immediately useful, we can provide deeper, more complete genetic information for patients and clinicians making critical clinical decisions.”

RNA analysis is now in use as a component of Invitae’s VUS resolution program as applied to  Invitae’s hereditary cancer syndrome gene testing, with broader application in other disease areas planned for later this year.

 

SOURCE Invitae Corporation

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New Research Reveals SafelyYou’s AI-Enabled Fall Detection Reduces Need for Emergency Service Care in Dementia Care Facilities

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Real-time fall detection using SafelyYou’s artificial intelligence-enabled video recording reduced the need for emergency services by a staggering 80% in dementia care facilities, according to research results published in the American Journal of Managed Care. The study closely examined the impact of SafelyYou’s memory care-focused technology to detect falls, videotape falls and notify care staff so that video review of the incident could occur immediately after each fall.

“According to the Alzheimer’s Association Report (2016), fall injury is the leading cause of Alzheimer dementia–related hospitalizations, with $5.3 billion in annual cost to Medicare,” said Glen Xiong, Advisory Board Member for SafelyYou. “In residential care facilities, individuals with dementia fall, on average, four times per year and twice as often as other residents. Falls often go unwitnessed. Due to uncertainty regarding the seriousness of each fall, facility staff frequently activate local emergency medical teams to examine the residents, and such visits often result in emergency department visits.”

The study, supported in part by a National Institutes of Health, National Institute of Aging Small Business Innovation Research Grant, was conducted with enrolled participants on June 1 to Aug. 31, 2018. Fall incidents and outcomes were routinely recorded for facility residents, and facility staff reviewed the falls in real time, immediately after each incident, for study participants.

Among 147 falls in the control group, 52 (35.4%) resulted in EMT visits and 36 (24.5%) resulted in ED visits. In contrast, the intervention group had 83 falls, with 13 (15.7%) and seven (8.3%) resulting in EMT and ED visits, respectively. There were relative reductions of 75% in EMT visits and 80% in ED visits.

The AI-enabled camera fall detection system coupled with staff review of fall videos led to more accurate identification of serious falls and incidents compared with less serious falls, such as when a resident intentionally moved to the ground but did not fall.

“Using emergency services less frequently leads to lowered healthcare costs and stress for everyone,” said George Netscher, CEO of SafelyYou. “Speaking with families and hearing the testimonials is really the very best part of our day.”

For more information on the pilot study results, visit: American Journal of Managed Care. To learn more about reducing falls and ED visits for residents in memory care, contact info@safely-you.com.

 

SOURCE SafelyYou

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Metadata.io Emerges as MarTech Force with Rapid Company Growth and Leader Position in G2 Crowd Summer 2019 Momentum Grid® Report for Account-based Execution

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Metadata.io (https://www.metadata.io/), the AI-powered account-based advertising platform for predictable B2B lead generation, today announced it is fast rising as a leader in the MarTech industry based on customer satisfaction. As a second-place Leader in G2 Crowd’s Summer 2019 Momentum Grid® Report for Account-based Execution, Metadata helps CMOs deliver a qualified pipeline to sales organizations by generating a predictable flow of inbound MQLS from within their target accounts.

Metadata customers like Nutanix, Nexmo and others have repeatedly won awards for best performing campaigns on LinkedIn and Facebook. They are among a growing list of early adopters that are achieving the industry’s top benchmarks in customer acquisition and ROAs using Metadata.

See the full Summer 2019 Momentum Grid Report here: http://bit.ly/2xGyaA5

“Our ranking is 100 percent attributed to our sophisticated customer base who bravely adopted early AI technology and achieved great ROI multiplier through automation and experimentation,” said Gil Allouche, CEO of Metadata. “Together, we are transforming marketing operations with AI. With Metadata, B2B marketers gain unprecedented ROI from digital investment, in a more predicted, measured fashion.”

“Our investment with Metadata empowered us to automatically target and convert sales-qualified leads that not only impacted revenue, but completely automated and simplified the execution of our account-based campaigns,” said Rob Bethell, Marketing Manager at RStudio.

For the quarterly Grid Momentum Report, G2 Crowd rates products based on reviews gathered from the user community, as well as data aggregated from online sources and social networks. The Momentum Grid for Account-based Execution is based on scores calculated using the G2 Satisfaction algorithm and G2 Momentum algorithm from reviews collected through May 29, 2019. In the Summer 2019 momentum report, Metadata showed strong growth in reviews, social and web.

 

SOURCE Metadata.io

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Knowmatix: An Online Educational Platform for the Cryptocurrency Industry

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Knowmatix is an online, in-depth educational platform providing the fundamentals and practical skills necessary to become successful in the Blockchain, Cryptocurrency industry from the comfort of your own home.

By applying our easy to understand, proven methods and applications, it is now easier than ever to successfully become a knowledgeable leader in blockchain technologies industry through our online accelerated educational program.  Our comprehensive introductory program provides a fundamental understanding of how various blockchains operate and how easy it is to strategically trade cryptocurrency in today’s centralized economy.

Our founder and curriculum developer, Abdulaziz AlYaqout, is currently operating in Miami Beach, Florida.  Prior to forming Knowmatix, Mr. AlYaqout took lead as an important consultant for the business analyst team at Ryder Systems, Inc. and the University of Miami Hospital and Clinics.  He holds BS Degree and MS in Industrial Engineering, both from the University of Miami.

As lead instructor for Knowmatix, Mr. AlYaqout’s first course is a blockchain and digital currency microdegree that provides you the basic tools to start and advance your professional career in the cryptocurrency.

Learn the technical analysis basics and terminology and develop buying strategies and skills to grow your personal finances. Learn how to deconstruct the blockchain technology, and the importance of Hashing.  Discover Bitcoin and understand its history and role in the cryptocurrency marketplace.

Knowmatix, seeks to create a Knowmatix Impact Program (KIP) that forms strategic alliances with reputable businesses operating in the Blockchain industry. This involves Knowmatix assigning project managers to given projects, and delegating work per project basis to qualified star students. While forming alliances with businesses, Knowmatix will align itself with schools and institutions to provide a custom backend solutions curriculum to help revamp their online courses. This effort provides colleges and institutions cost saving measures by offering its platform in a software program, which acts as an additional resource to aid students with completing their education, and securing a career through Knowmatix alliances and partners in the ever growing technology field, nationwide.

With Knowmatix’ proprietary platform and blockchain-focused training services, Mr. AlYaqout ventures to be part of the governmental effort to Buy American and Hire American with special interest for advancing the careers of woman and Veteran groups nationwide to team up with Knowmatix.

For additional information and preview of our proprietary educational curriculum, please visit our website at www.knowmatix.com.

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What You Will Learn

  • Cryptocurrency terminology
  • Deconstructing blockchain technology
  • Understanding Hashing
  • Digital Currency and its Future
  • Bitcoins role and history
  • Currency wallets
  • Crypto Research tools
  • Buying strategies
  • Digital Asset Classifications
  • Blockchain Analysis Basics

 

SOURCE Knowmatix

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