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Biotech Companies Making Strides in Pancreatic Cancer Treatment and Early Detection
USA News Group Commentary Issued on behalf of Oncolytics Biotech Inc.
VANCOUVER, BC, May 15, 2024 /PRNewswire/ — USA News Group – Hope is rising in the fight against one of the deadliest cancers in the world, as a new study recently claimed that a blood test can accurately detect early-stage pancreatic cancer with 97% accuracy. According to Johns Hopkins Medicine, up to 10% of patients who receive an early diagnosis become disease-free after treatment, meaning the earlier it’s detected, the better the patient’s chances to survive. The American Cancer Society estimates that about 66,440 people (34,530 men and 31,910 women) will be diagnosed with pancreatic cancer in the USA this year, projecting about 51,750 people will succumb to the disease. Working diligently behind the scenes, several biotech drug developers are making progress in new treatments, including recent updates from Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Candel Therapeutics, Inc. (NASDAQ: CADL), ABVC BioPharma, Inc. (NASDAQ: ABVC), CytomX Therapeutics, Inc. (NASDAQ: CTMX), and Amgen Inc. (NASDAQ: AMGN).
Pelareorep, an intravenously delivered immunotherapeutic agent being developed by Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), is gaining momentum as a potential treatment for multiple cancers, especially breast cancer and pancreatic cancer. In late 2022, the FDA granted pelareorep Fast Track Designation for treating pancreatic cancer, following promising clinical results. Now Oncolytics has recently announced a preliminary collaboration with the Global Coalition for Adaptive Research (GCAR), with the purpose of commencing planning activities for the evaluation of pelareorep in the treatment of first-line metastatic pancreatic ductal adenocarcinoma (PDAC), as part of GCAR’s anticipated master protocol for metastatic pancreatic cancer.
GCAR’s activities are already underway to finalize the seamless Phase 2/3 master protocol design that will evaluate multiple investigational therapies for pancreatic cancer treatment. Thus, the intent of the pelareorep study will be to produce registration-enabling data.
“We are thrilled to collaborate with GCAR and are honored that pelareorep has been selected as the first therapeutic for evaluation in GCAR’s planned adaptive trial in pancreatic cancer patients,” said Dr. Matt Coffey, President and Chief Executive Officer of Oncolytics. “We believe this opportunity presents a strategic and efficient pathway forward for the development of pelareorep to address an urgent need for pancreatic cancer patients. GCAR’s anticipated trial design seeks to cut registrational study time and reduce trial costs, speeding up the journey to potentially deliver effective cancer treatment sooner.”
Oncolytics is also now advancing its lead asset further, having recently received regulatory clearance to evaluate pelareorep in combination with modified FOLFIRINOX +/- Tecentriq (from Roche) in pancreatic cancer in a new cohort from its ongoing GOBLET study, following German regulatory and ethics approvals. The new cohort is bolstered by a US$5 million Therapeutic Accelerator Award from the Pancreatic Cancer Action Network (PanCAN), an inventive initiative aimed at rapidly advancing the development of new treatments for pancreatic cancer.
Achieving these positive results from the pelareorep/mFOLFIRINOX combination could greatly elevate Oncolytics’ prospects in tackling pancreatic cancer. Oncolytics has previously reported encouraging data from pelareorep paired with gemcitabine and nab-paclitaxel. The Oncolytics team believes that if the mFOLFIRINOX combination demonstrates improvements in response rate over historical control trials, this treatment approach could move forward to a registration-enabling study, offering two potential pelareorep-based therapies for pancreatic cancer patients. Additionally, planned translational research studies for this cohort will further explore the understanding of pelareorep’s mechanism of action, including its impact on the tumor microenvironment (TME).
As a part of this evaluation, Oncolytics will examine the relationship between tumor responses and the expansion of tumor-infiltrating lymphocytes (TILs) in the blood, an effect noted in previous pancreatic cancer studies. The company plans to start enrolling patients into the mFOLFIRINOX/pelareorep study cohort in Q2 2024.
For Candel Therapeutics, Inc. (NASDAQ: CADL), the FDA granted Orphan Drug Designation to their leading multimodal biological candidate, CAN-2409, for pancreatic cancer treatment. This recognition came shortly after Candel shared updated overall survival data from its ongoing randomized phase 2 clinical trial of CAN-2409 combined with valacyclovir (prodrug) and standard-of-care chemoradiation, followed by surgery for borderline resectable pancreatic ductal adenocarcinoma (PDAC).
“We recently reported data from the phase 2 randomized clinical trial of CAN-2409 in borderline resectable pancreatic cancer, showing that CAN-2409, when added to standard of care, more than doubled the median overall survival obtained with standard of care alone,” said Paul Peter Tak, MD, PhD, FMedSci, President and CEO of Candel. “We are pleased that the FDA has now granted Candel with both Orphan Drug and Fast Track Designation to this program, as we seek to reshape the treatment paradigm in pancreatic cancer.”
Clinical-stage biopharmaceutical company ABVC BioPharma, Inc. (NASDAQ: ABVC) recently announced it has entered into a definitive agreement with private company OncoX BioPharma, Inc. in its fight against pancreatic cancer. Through its affiliate Rgene Corporation, ABVC and OncoX are set to collaborate on combination therapy the duo believes will help treat pancreatic cancer and improve patient outcomes significantly, with ABVC and Rgene set to receive an aggregate license fee of $12.5 million in cash or shares from OncoX within the next 30 days.
“We are excited to announce this collaboration with OncoX, which represents a significant step forward in our commitment to developing transformative treatments for pancreatic cancer,” said Dr. Uttam Patil, CEO of ABVC. “By combining our strengths, we can make meaningful progress in addressing this devastating disease. The collaboration will draw on ABVC’s portfolio of combination therapies pipeline, which has shown promise in preclinical and early clinical studies.”
Among ABVC’s portfolio is its ABV-1703 (IND 136309) for pancreatic cancer therapy. As part of an Investigational New Drug (IND) application for ABV-1703 is the proposal for the clinical investigation of BLEX 404 as a combination therapy drug with chemotherapy. BLEX 404 is made with the active ingredient glucan, which is extracted from Grifola frondose (maitake mushrooms), an edible fungus with high medical and commercial value in Asia.
“This partnership exemplifies our dedication to advancing the field of oncology and bringing hope to patients facing pancreatic cancer,” said Wen-Pin Yen, CEO of OncoX. “Together with ABVC, we are committed to pushing the boundaries of innovation to improve outcomes for patients in need. The two companies aim to deliver a novel treatment option for pancreatic cancer patients by combining their resources, expertise, and innovative approaches.”
Leading drug developer in the field of masked, conditionally activated biologic therapeutics, CytomX Therapeutics, Inc. (NASDAQ: CTMX), recently announced positive initial data from its ongoing CX-904 Phase 1a dose escalation clinical study with its global development partner, Amgen Inc. (NASDAQ: AMGN). CytomX and Amgen are collaborating on CX-904, a bispecific PROBODY candidate designed to engage T-cells by targeting the epidermal growth factor receptor (EGFR) on cancer cells and the CD3 receptor on T cells.
Within the clinical study results, CX-904 not only demonstrated a favorable safety profile with no cytokine release syndrome, but also presented encouraging initial signs of efficacy observed for CX-904 in advanced pancreatic cancer, including 2 of 6 patients (33%) with a confirmed partial response, and all 6 patients (100%) with disease control.
“We are delighted to share these initial results today for CX-904, a highly innovative masked T-cell engager that embodies our vision at CytomX of transforming lives with safer, more effective therapies,” said Sean McCarthy, D.Phil., CEO and Chairman of CytomX. “These data build on more than a decade of innovation at CytomX, and, we believe, open broad new possibilities for T-cell engagers across many targets and cancer types. We look forward to continuing to explore the potential of this exciting agent in multiple EGFR positive cancers and to determining longer term strategy with our global development partner, Amgen.”
Article Source: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/
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Latest News
COCA Celebrates Q2 2024 with Record-Breaking Milestones and New Launches
HONG KONG, Aug. 7, 2024 /PRNewswire/ — COCA, a pioneering force in the crypto wallet and financial services industry, has achieved several remarkable milestones in Q2 2024. Thanks to the steadfast support of its user community, COCA has launched new features, expanded its partnerships, and garnered prestigious accolades, further solidifying its position as a leader in the crypto space.
Launch of Physical Cards
COCA has introduced its highly anticipated physical cards, which are now available globally and compatible with Apple Pay and Google Pay. These cards allow users to make transactions with ease, earning cashback rewards on their purchases. This significant launch marks a step forward in integrating crypto with everyday financial activities, enhancing user convenience and financial flexibility.
Wallet Growth Milestone
The company has reached a significant milestone with 510,000 active wallets, reflecting a 102% growth quarter-on-quarter. This surge in active wallets highlights the increasing trust and adoption of COCA’s platform, as more users join the COCA community to manage their crypto assets securely and efficiently.
Transaction Volume Surge
In Q2 2024, COCA processed over USD 450,000 in transactions through its platform, demonstrating the robust usage and popularity of its financial services. This impressive transaction volume underscores COCA’s commitment to providing smooth and efficient crypto payment solutions.
Integration with Revolut
COCA has made it easier for users to fund their wallets by integrating with Revolut. This new feature allows seamless loading of crypto assets, enhancing the overall user experience and accessibility of COCA’s services.
Award Recognition
COCA has been honoured with the “Best Startup” award in the Financial Revolution category at CONF3RENCE & BLOCKCHANCE 2024. This award is a testament to COCA’s innovative approach and significant impact on the future of finance, recognizing its efforts in driving forward the digital financial ecosystem.
New Strategic Partnerships
COCA has formed strategic partnerships with industry leaders such as Wirex Pay and GoMining. These collaborations aim to provide users with enhanced rewards and a superior overall experience. The partnerships signify COCA’s dedication to expanding its ecosystem and delivering greater value to its users.
Welcoming Pavel Matveev
COCA is excited to announce the addition of Pavel Matveev, Founder of Wirex, to its team as a Strategy and Product Advisor. Pavel’s extensive experience and visionary approach are expected to drive COCA’s strategic initiatives and product development, contributing to the company’s continued growth and innovation.
Season 2 Point System Launch
Season 2 of COCA’s popular point system has launched, offering users the opportunity to earn points through various activities, including trades, referrals, holding assets, and spending with COCA cards. With a prize pool of USDT 3500 and 5 Wirex Pay Nodes, this season promises exciting rewards and increased user engagement. The season ends on August 9th, so users are encouraged to participate actively.
NFT Giveaway
In a special giveaway, COCA distributed 1000 GoMining NFTs to lucky users. These NFTs provide unique benefits, including enhanced mining capabilities and exclusive digital collectibles, adding significant value to the user experience.
For further details on COCA’s Q2 achievements and upcoming initiatives, visit the company’s blog.
Website: coca.xyz
COCA continues to redefine the crypto experience with its innovative solutions, seamless integrations, and user-focused approach. The company’s recent milestones and future plans highlight its commitment to leading the way in the digital financial landscape.
About COCA
COCA is a next-generation crypto super app designed to simplify and secure the crypto experience for users worldwide. With innovations in security, usability, and integration, COCA is at the forefront of the digital asset revolution. For more information, visit coca.xyz.
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Latest News
Stake and Earn with KuCoin’s Innovative GemPool Platform
VICTORIA, Seychelles, Aug. 7, 2024 /PRNewswire/ — KuCoin, a leading global cryptocurrency exchange, is excited to announce the launch of GemPool, its innovative new platform that allows users to acquire token airdrops as a reward for staking their crypto assets. This unique product is designed to provide early access to emerging crypto projects while offering rewards for their existing holdings at zero cost. By staking respective tokens in separate pools, users can farm new tokens and gain a foothold in the latest developments within the cryptocurrency market.
GemPool also offers flexible staking terms, allowing users to stake and un-stake their assets anytime within the designated period without lock-up restrictions. This flexibility ensures that users can manage their assets according to their preferences and market conditions. Additionally, GemPool provides zero-cost rewards, enabling users to earn tokens while holding their existing cryptocurrencies. By staking their tokens, users contribute to the growth of promising new projects, supporting innovation and development within the crypto space. With completion of tasks offered, users are eligible to earn multiplier bonus and receive more rewards.
Users can participate by staking KCS, USDT, or other specified assets in designated pools. The rewards are earned according to the respective yields of the pools, ensuring a fair and exciting experience for all users.
For more information on how to participate and the benefits of GemPool, please visit the KuCoin GemPool page.
About KuCoin
Launched in September 2017, KuCoin is a leading cryptocurrency exchange with its operational headquarters in Seychelles. As a user-oriented platform with a focus on inclusiveness and community engagement. It offers over 900 digital assets across Spot trading, Margin trading, P2P Fiat trading, Futures trading, and Staking to its 34 million users in more than 200 countries and regions. KuCoin ranks as one of the top 6 crypto exchanges. KuCoin was acclaimed as “One of the Best Crypto Apps & Exchanges of June 2024” by Forbes Advisor and has been included as one of the top 50 companies in the “2024 Hurun Global Unicorn List”. Learn more at https://www.kucoin.com/.
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Trust Wallet Launches Gamified Education Platform and Loyalty Program to Enhance and Reward Web3 Learning
DUBAI, UAE, Aug. 7, 2024 /PRNewswire/ — Trust Wallet, the world’s leading self-custody Web3 wallet and Web3 gateway trusted by over 130 million users, has launched Trust Wallet Quests, a gamified education platform within the Trust Wallet mobile app which encourages users to earn points while exploring and learning about Web3.
Users can engage in task-based challenges ranging from quizzes to complex problem-solving scenarios composed of various DeFi and Web3 activities, all designed to deepen their understanding of blockchain technology and decentralized applications (dApps), and expose them to exciting opportunities within Web3. As an incentive, users will earn Trust Points, a loyalty-based points system designed to reward user activity within the Trust Wallet mobile app. With Trust Points, users can earn rewards upon the completion of specific tasks, making Web3 more rewarding and fun.
In the future, Trust Points will offer additional gamification features, such as unlocking achievements, badges, and levels. This interactive approach not only boosts individual learning but also contributes to broader community education and adoption of decentralized technologies, making Trust Wallet Quests a dynamic and exciting way to reward loyal users and engage with communities in Web3.
On the motive for launching Trust Wallet Quests, Eowyn Chen, CEO of Trust Wallet, stated: “The complex technology and fast-paced industry can be intimidating for both new and seasoned users. The introduction of Quests on Trust Wallet further solidifies our commitment to making it easier for millions to navigate Web3, aligning perfectly with our mission to build a seamless Web3 hub and open ecosystem for all.”
Nate Zou, Head of Product at Trust Wallet, highlighted what to expect from Trust Points and Trust Wallet Quests: “Trust Points and Quests are just the first iteration of a much-needed reward system for our community. Within 2024, we have plans to build on this, combining rewards with many of our other web3 product offerings. Overall, we envision this points system not only changing how users engage with Trust Wallet, but also encouraging more collaboration between Trust Wallet, our users and other web3 ecosystem players.”
Trust Wallet Quests and Trust Points are now available on both Android and iOS versions of Trust Wallet’s mobile app. Download here: https://short.trustwallet.com/TrustWalletQuests
About Trust Wallet
Trust Wallet is the self-custody, multi-chain Web3 wallet and Web3 gateway for people who want to fully own, control, and leverage the power of their digital assets. From beginners to experienced users, Trust Wallet makes it easier, safer, and convenient for millions of people around the world to experience Web3, access dApps securely, store and manage their crypto and NFTs, buy, sell, and stake crypto to earn rewards, all in one place and without limits.
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