LONDON and NEW YORK, Sept. 18, 2023 /PRNewswire/ — ICIS has announced the ICIS Top 100 Chemical Companies, a global listing of the leading producers of chemicals worldwide ranked by 2022 sales.
Germany-based BASF is again the world’s largest chemical company, with sales of $93.7bn in 2022, up 11.1% versus 2021.
Rounding out the Top 5 are China-based Sinopec with $78.2bn in chemical sales, followed by US-based Dow in third with $56.9bn, Saudi Arabia-based SABIC with $52.9bn and UK-based INEOS with $51.9bn.
While most chemical companies generated sales growth in 2022 on higher oil and natural gas feedstock costs, margins were squeezed, particularly in the back half of the year.
“After a robust H1 on tailwinds from the pandemic recovery, by Q3 deteriorating macroeconomic conditions and a shift in consumer spending away from durables led to an unprecedented stretch of destocking continuing well into 2023 with impacts still being felt today,” said Joseph Chang, Global Editor of ICIS Chemical Business.
“2022 will go down as one of the most difficult years for chemical companies since the Global Financial Crisis, as it was overshadowed by war and looming economic recession, although for some, the impact of these seismic events did not materialise until late in the year,” said Nigel Davis, ICIS Insight Editor.
The ICIS Top 100 Chemical Companies includes sales as well as operating profits, net income, total assets, capital expenditures and R&D spending for the world’s top producers.
The ICIS Top 100 Chemical Companies issue of ICIS Chemical Business is available for download here.
Currency conversions to US dollars for the ranking are based on year-end 2022 exchange rates.
ICIS – Independent Commodity Intelligence Services – helps businesses through seamlessly delivering data and analytics, across the chemical, fertilizer and energy markets. A trusted source and benchmark for price information and insight across key commodities markets worldwide. Our independent, transparent market intelligence informs thousands of quality decisions every day, taking the pressure out of negotiations and giving customers space for more innovative thinking, through published datasets including price assessments, price forecasts, supply and demand fundamentals and more. Over 150 years of shaping the world by connecting markets to optimise the world’s valuable resources. With a global team of more than 600 experts, ICIS has employees based in London, New York, Houston, Karlsruhe, Milan, Mumbai, Singapore, Guangzhou, Beijing, Shanghai, Dubai, Sao Paulo, Seoul, Tokyo and Perth.
ICIS is part of RELX, a FTSE15 company with a market cap of £52.9bn and an employee base of over 35,000 experts across 40 countries.
RELX is a global provider of information and analytics for professional and business customers across industries. The Group serves customers in more than 180 countries and has offices in about 40 countries. It employs approximately 30,000 people of whom almost half are in North America. RELX PLC is a London listed holding company which owns 52.9% of RELX Group. RELX NV is an Amsterdam listed holding company which owns 47.1% of RELX Group. The shares are traded on the London, Amsterdam and New York Stock Exchanges using the following ticker symbols: London: REL; Amsterdam: REN; New York: RELX and RENX. Total market capitalisation is approximately £52.9bn | €61.5bn | $65.6bn
The Office of the Executive Committee of the WMC Released the List of “Top 500 Chinese Manufacturing Enterprises in 2023”
HEFEI, China, Sept. 22, 2023 /PRNewswire/ — The 2023 World Manufacturing Convention (WMC) was opened on September 20 in Hefei, Anhui Province, China. In the convention, the list of “Top 500 Chinese Manufacturing Enterprises in 2023” was released, indicating that the operating revenue of China’s top 500 manufacturing enterprises in 2023 has exceeded 50 trillion RMB for the first time, reaching 51.06 trillion RMB, which was an increase of 8.38%.
Among the top 500 manufacturing enterprises, the heavy chemical industry still occupies the main position, and four out of the five industries with the largest operating revenue belong to the heavy chemical industries. Meanwhile, the pace of development of strategic emerging industries has accelerated, and most of the enterprises with the top operating revenue and net profit growth are strategic emerging industry enterprises. The top five industry’s average revenue growth rates are from power batteries and energy storage batteries, wind energy, solar equipment manufacturing, medical equipment manufacturing, computer and office equipment and chemical fiber manufacturing, of which the top three growth rate reached more than 45%, respectively 59.72%, 49.42%, 45.54%. According to the analysis of the ranking, the total R&D expenses of China’s top 500 manufacturing enterprises in 2023 have reached 109.6215 billion RMB, which was an increase of 3.83% over the previous year; the R&D intensity was 2.33%, which is at a high level in recent years. The average R&D expenses of industries such as aerospace, communication equipment manufacturing, railway traffic equipment manufacturing, textile printing and dyeing are at the forefront from the perspective of various industries.
The “2023 Development Report on Anhui Manufacturing” prepared by the Anhui Provincial Department of Economy and Information Technology was also released on the day of the convention. The report shows that the average annual growth rate of industrial value added of enterprises above the designated size in Anhui Province was 9.5% from 2012 to 2022, ranking the first in the central region, the first in the Yangtze River Delta and the fourth in whole China. In 2022, the province’s industrial enterprises above the designated size have achieved an operating revenue of 4.9 trillion RMB, ranking 10th in the country. Among them, manufacturing enterprises above the designated size have achieved an operating revenue of 4.4 trillion RMB; the added value of the manufacturing industry has exceeded 1 trillion RMB, accounting for 26.5% of GDP, which was an increase of 0.3 percentage points over the previous year.
In recent years, Anhui’s manufacturing industry has accelerated the development of integrated clustering, especially the clustering of advanced manufacturing chains, forming an unformidable trend. The top one industry is “automobile” with irresistible force, while the PV and energy storage gathering “sparkling light” into a raging torch, the IC industry showing its brilliant “core”, the new “displays and screens” experiencing a rapid boom, and the AI “valley” astonishing the world. A number of industrial landmarks have become an important force leading the trend of China’s and even the world’s manufacturing industry.
Contact: Yuan Fan
Tel: 0086- 13552640063
E-mail: [email protected]
Asian International Arbitration Centre and SOAS University of London, Arbitration and Dispute Resolution Centre sign MoU to promote best practice in arbitration
LONDON, Sept. 22, 2023 /PRNewswire/ — The Asian International Arbitration Centre (AIAC), Kuala Lumpur, and SOAS University of London, Arbitration and Dispute Resolution Centre (SADRC) have yesterday (Thursday 21 September) signed a Memorandum of Understanding to advance collaboration and promote best practice in alternative dispute resolution techniques, including arbitration.
The MoU will see the AIAC and SADRC further develop teaching and research activities in alternative dispute resolution in line with international best practice, to coordinate efforts to promote the use of alternative dispute resolution.
Azalina Othman Said, Malaysia’s Minister of Law and Institutional Reform, was in London to attend the MoU signing, and offer it Malaysia’s full support to increase dialogue in arbitration. The Minister attend the MoU signing alongside Malaysia’s High Commissioner to the UK Dato’ Zakri Jaafar, Solicitor General II of the Attorney General’s Chambers of Malaysia, Datuk Almalena Sharmila binti Dato’ Dr. Johan, and Deputy Director General of the Legal Affairs Division of the Prime Minister’s Department, Dr. Punitha Silivarajoo. The Head of Legal Services Trade and Promotion at the UK Ministry of Justice, Holly O’Callaghan, attended to offer the UK Government’s support.
Speaking about the MoU signing, Emilia Onyema, Professor of International Commercial law, SOAS & Director, SADRC, said:
“At the SADRC, we are proud that today we have become a partner of the Asian International Arbitration Centre. Through signing this MoU, we hope to promote alternative dispute resolution techniques in our SOAS regions, Asia, Middle East and Africa, and particularly Malaysia, and learn from our shared experiences.”
Sundra Rajoo, Director of AIAC, said:
“We are delighted that today, the Asian International Arbitration Centre has formally agreed a MoU with SOAS University of London’s prestigious new Arbitration and Dispute Resolution Centre. The formalization of the MoU between both institutions is indeed a remarkable and significant achievement. We firmly believe that through this innovative partnership, we can enhance our joint efforts to promote best practices in alternative dispute resolution, benefiting not only the UK and Malaysia but also the broader Asian and African region.”
Azalina Othman Said, Malaysia’s Minister of Law and Institutional Reform, said:
”The UK and Malaysia have a long shared history of collaborating to tackle mutual challenges, and the signing of the MoU between the Asian International Arbitration Centre and SOAS University of London’s Arbitration and Dispute Resolution Centre underscores the depth of our relationship and our commitment to advancing global best practices in arbitration.”
In practical terms, this collaboration would include steps to encourage, enhance and promote the following areas of cooperation:
- Joint courses and training;
- Joint research programmes;
- Contribution of expertise – such as researchers, panellists, speakers and guest lecturers – to initiatives which share common goals;
- Publication of academic journals, books and newsletters;
- Student internship programmes;
- Organising or hosting joint conferences, workshops, seminars and forums.
In addition to arbitration, the two centres have committed to also promote Islamic arbitration, sports arbitration, mediation, adjudication, and domain name dispute resolution as alternative dispute resolution methods.
The MoU signing comes ahead of the inaugural London International Arbitration Colloquium, which will take place on Monday 25 September at the International Dispute Resolution Centre in London, to consider the role of international arbitration involving sovereign states.
Over the course of three panel sessions, guests will hear expert insights on jurisdictional challenges in investment arbitration, the impact of investment claims on states and their sovereignty, and the role of third-party funding in access to justice.
For more information, contact:
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Revolutionary Cancer Treatment Advances Promise Brighter Future Amid Federal Funding Uncertainty
FN Media Group Presents USA News Group News Commentary
VANCOUVER, British Columbia, Sept. 22, 2023 /PRNewswire/ — USA News Group – Despite the potential federal funding challenges due to the recent debt ceiling deal, optimism in the battle against cancer persists, thanks in large part to the audacious “Cancer Moonshot” initiative. This ambitious plan, aimed at halving cancer rates within the next quarter-century, continues to fuel hope even as concerns about the stability of National Institutes of Health (NIH) funding arise. In these turbulent times, the resilience and ingenuity of the biotech sector provide a beacon of hope. For instance, Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Zymeworks Inc. (NASDAQ: ZYME), Jazz Pharmaceuticals plc (NASDAQ: JAZZ), Protagonist Therapeutics, Inc. (NASDAQ: PTGX), and Amgen Inc. (NASDAQ: AMGN), have each demonstrated inspiring progress and unwavering commitment in advancing cancer treatments, highlighting their vital role in the future of cancer therapy.
At the 2023 ASCO Annual Meeting Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC) shared exciting results from its important study, called BRACELET-1, with results that caught the eye of RBC Capital. The oral presentation shared at the event described how they’ve been testing a treatment for advanced breast cancer, and it’s looking very promising.
The treatment combines Oncolytics’ flagship drug, pelareorep, with a well-known cancer medicine, paclitaxel. Pelareorep is a unique drug that targets and kills cancer cells by making them self-destruct while leaving healthy cells unharmed. The results of BRACELET-1 showed that this mixture could slow down the cancer significantly. It even lowered the risk of the cancer getting worse by a significant 71% compared to just using paclitaxel.
For people battling cancer, this means more quality time before the cancer might get worse. Specifically, people getting the combined treatment had about 9.5 good months before the disease advanced, compared to just 6.3 months with only paclitaxel.
Moreover, the new treatment was better at shrinking or even eliminating the cancer. An impressive 37.5% of patients responded to the combined treatment, as opposed to just 13.3% with paclitaxel alone.
“BRACELET-1’s positive results complement prior phase 2 data showing a statistically significant increase in overall survival when pelareorep was combined with paclitaxel by demonstrating similar robust improvements in PFS and ORR in less heavily pre-treated patients,” said Dr. Matt Coffey, President and CEO of Oncolytics Biotech. “Given this exciting finding, our next step is to discuss our data with the FDA to investigate incorporating dual PFS and OS endpoints into our breast cancer program’s registrational study. Including a PFS endpoint will substantially reduce the time to a pivotal readout from the registrational trial, thereby accelerating pelareorep’s path to potential approval as we work to address the urgent needs of HR+/HER2- breast cancer patients.”
Following these encouraging results, Oncolytics Biotech is now ready to take the next steps in advancing its breast cancer program. They’re planning to talk to the FDA and push forward with more registrational studies, having already received Fast Track Designation for pelareorep in the treatment of advanced/metastatic pancreatic cancer, in late 2022. This could make pelareorep an approved treatment for breast cancer sooner than expected.
Another highlight from the ASCO presentations was that of Jazz Pharmaceuticals plc (NASDAQ: JAZZ) and Zymeworks Inc. (NASDAQ: ZYME). Together the two companies presented promising data from a pivotal Phase 2b trial, evaluating the bispecific antibody, zanidatamab, in HER2-amplified biliary tract cancers (BTC), a particularly aggressive group of cancers that currently lack HER2-targeted treatment options.
The results were not only presented at ASCO but also concurrently published in The Lancet Oncology. They demonstrated meaningful clinical benefit, including antitumor activity, a confirmed objective response rate (cORR) of 41.3%, a median duration of response (DOR) of 12.9 months, and a median progression-free survival (PFS) of 5.5 months.
“The HERIZON-BTC-01 trial advances an exciting field of oncology research where we can leverage next-generation sequencing on BTC patients to understand genomic markers of the disease and choose the appropriate targeted therapies for these patients,” said Shubham Pant, M.D., professor of Gastrointestinal Medical Oncology and Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center.
The data clearly outshines current chemotherapy treatments for BTC, which offer only a 5 to 15 percent ORR and median PFS of 1.4 to 4 months. The Zymeworks-Jazz partnership showcased an oral presentation on the pivotal HERIZON-BTC-01 study results demonstrating zanidatamab’s meaningful clinical benefit and tolerable safety profile in patients with HER2-amplified BTC.
Zanidatamab has already been granted Breakthrough Therapy designation and two Fast Track designations by the FDA, making it an exciting contender in the fight against these tough-to-treat cancers. These exciting results suggest a potential future where targeted treatments like zanidatamab transform the lives of patients in critical need.
With three oral presentations and two poster discussions, and over 25 abstracts, Amgen’s (NASDAQ: AMGN) presence at ASCO included new scientific and clinical research across its diverse oncology portfolio and pipeline, featuring data in hard-to-treat tumor types like non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and small cell lung cancer (SCLC).
“Our presentations at ASCO… illustrate how we’re advancing novel approaches to address the toughest thoracic and colorectal cancers with limited treatment options,” said David M. Reese, M.D., executive vice president of Research and Development at Amgen. “We’re focused on expanding the reach and impact of our transformative, first-in-class medicines to help more people living with cancer.”
Highlights from Amgen’s presentations included data on LUMAKRAS® (sotorasib) from the first study evaluating its intracranial efficacy as a KRAS G12C inhibitor versus docetaxel in treated KRAS G12C-mutated advanced NSCLC. Additional analyses from DeLLphi-300 highlighted the safety and clinical efficacy of Tarlatamab, an investigational first-in-class BiTE® immunotherapy, in patients with SCLC with treated and stable brain metastases. Other studies presented novel combinations showing encouraging safety and efficacy in pre-treated KRAS G12C-mutated metastatic CRC and first-line NSCLC.
These presentations showed advances in several therapeutic areas, including hematologic malignancies, melanoma/skin cancers, and gastrointestinal cancers. Some of the key clinical studies presented include the IKEMA study for KYPROLIS®, the PARADIGM trial for VECTIBIX®, and a phase 2 study on IMLYGIC® in advanced sarcoma.
One company also potentially (yet indirectly) making significant strides in the oncology sector is Protagonist Therapeutics, Inc. (NASDAQ: PTGX), a Newark, California-based biopharmaceutical firm. Although not traditionally labeled as a cancer biotech firm, their innovative approach towards blood disorders, notably Polycythemia Vera, a slow-growing blood cancer, underscores their contribution to the broader oncology landscape.
Protagonist’s leading drug candidate, rusfertide (PTG-300), is currently under the microscope. The company recently announced that additional data from the REVIVE study of rusfertide in polycythemia vera would be presented at the annual Congress of the European Hematology Association (EHA). This study holds immense promise as it explores the ability of rusfertide to improve symptoms related to this blood disorder.
The Moffitt Cancer Center and the Department of Malignant Hematology have taken a keen interest in this study, suggesting rusfertide’s potential broader application in the field of hematology and possibly in other forms of cancer. An assistant member of the Department, Dr. Andrew Kuykendall, will present the study results, further demonstrating the deep links between Protagonist’s work and oncology professionals.
Moreover, Protagonist is also advancing their peptide-based new chemical entity, JNJ-2113 (formerly PN-235), which recently showed positive topline results in treating moderate-to-severe plaque psoriasis. While psoriasis is not a form of cancer, the advancement of these biological drugs signals a new direction in treating various human conditions, including cancers.
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- The Office of the Executive Committee of the WMC Released the List of “Top 500 Chinese Manufacturing Enterprises in 2023”
- Asian International Arbitration Centre and SOAS University of London, Arbitration and Dispute Resolution Centre sign MoU to promote best practice in arbitration
- Revolutionary Cancer Treatment Advances Promise Brighter Future Amid Federal Funding Uncertainty
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