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MGI: Closing the Cancer Care Gap with the Power of Precision Oncology
BERLIN, Feb. 4, 2024 /PRNewswire/ — According to American Cancer Society, Cancer causes about 1 in every 6 deaths globally, more than AIDS, tuberculosis, and malaria combined. Today, it is the first or second leading cause of death in most countries around the world. Technological advances in genomics have enabled the identification and improved understanding of causal factors and shed light on precision oncology.
February 4 marks World Cancer Day, an initiative aimed at promoting awareness on cancer as a public health issue and improving access to quality care, screening, early detection, therapy, and palliative care for those affected.
In this new era in precision oncology, researchers like Dr. Marie-Laure Yaspo from ALACRIS Theranostics (“ALACRIS”) and Dr. Xuan Gao and Dr.Huan Fang from GenePlus are working towards closing the care gap with evidence-based strategies in cancer control along the care continuum, from prevention to treatment, with help from MGI’s cutting-edge life science technologies.
ALACRIS innovates with its advanced tumor-agnostic molecular diagnostic test augmenting tailored treatment options
At ALACRIS Theranostics in Germany, co-founder and Chief Scientific Officer Dr. Marie-Laure Yaspo and her team are committed to provide every cancer patient with the highest standard of care through the Comprehensive Molecular Cancer Analysis (CMTA), a unique molecular diagnostic test designed to identify the best personalized treatment options for each patient, based on high-throughput sequencing of the exome (or genome) and transcriptome of their tumor.
“From past research in cancer genomics projects, we learned how complex and unique the molecular landscape of every tumor can be,” said Dr. Yaspo as she recalled her 12+ years in molecular genetics prior to establishing ALACRIS. “Only by collecting comprehensive information on the tumor landscape can we further develop and enhance personalized therapy.”
“Every patient is unique, every tumor is different,” added Dr. Yaspo. To capture this individuality, the CMTA technology integrates two layers of sequence data, DNA (genome or exome) and RNA (transcriptome), for a comprehensive analysis of the clinically relevant alterations in every tumor. In addition to mutations and chromosome copy number alterations, key features such as gene fusions, overexpressed oncogenes, immune microenvironment, and more provide essential information for the evaluation of the best therapeutic options.
“Starting from a tumor biopsy, the end-to-end Alacris-CMTA® process generates high-throughput sequencing data with MGI’s highly accurate and reliable platforms and deploys Alacris’s advanced bioinformatics analysis pipelines to deliver a comprehensive, interpreted tumor profiling report,” said Dr. Yaspo. “We interprete actionable alterations and match those with drug databases”, delivered a concise report guiding oncologists to design personalized therapies. The CMTA® fits the patient’s journey, and is particularly well suited for patients with refractory or rare cancers in need of treatment options. to improve their outcome.”
Back in 2022, MGI launched a Customer Experience Center at ALACRIS’s Berlin-based facility equipped with MGI’s DNBSEQ-G400* sequencer, MGISP-960 automation system and more. Not long after, in 2023, a new DNBSEQ-T7* sequencer was installed to further support the facility’s sequencing needs, including pediatric leukemias.
“The time that patients have is limited and precious. The faster we get sequencing samples analyzed, the sooner they can receive personalized treatment,” said Dr. Yaspo. “MGI platforms’ high flexibility and quick turnaround enable us to provide reliable diagnostics for a large number of patients. Its cost-effectiveness also makes it easier for more people to benefit from affordable and accessible cancer services, thereby contributing to better healthcare.”
GenePlus’ NGS total solution helps match cancer patients to precise therapy
Meanwhile in China, the team at GenePlus, including Dr. Xuan Gao and Dr. Huan Fang, Assistant Directors of the company’s Genomics Institute, has been studying tumor detection and intervention to help clinicians determine the safest and most effective treatment for cancer patients through clinical and scientific research.
“Having witnessed the pain and torment of someone close who suffered from cancer, I was determined to devote myself to cancer precision medicine,” said Dr. Gao. “In the 6+ years I’ve been in the field, high-throughput sequencing technology has rapidly promoted the development of tumor genomics research, giving us a better understanding of the genetic characteristics and molecular mechanisms of tumors, and thereby providing new targets and combination therapy options to alleviate patients’ suffering.”
Given the inherent complexity and heterogeneity of cancer, as well as its risks of genetic mutation, tumors are constantly evolving, which leads to drug resistance during treatment. Although the stratification of patients has been refined, there still lacks specific, tailor-made therapy options. At the same time, many advances in the field have yet to reach the masses due to high costs and insufficient clinical trial design and data. “MGI’s technology plays a critical role in helping us expanding precise tumor tests and genome-driven drug strategies for patients, including those who currently cannot use targeted therapy,” added Dr. Gao.
The GenePlus NGS total solution, which includes certified kits, library workshops, genetic sequencers, and the GeneBox informatic platform, facilitates faster, simpler and more reliable cancer sequencing. Benefitting from DNBSEQ’s high quality, accuracy and cost-effectiveness, the solution creates a pipeline of tumor precision medication, whole-process case, and pathogen detection. To date, it has been deployed in more than 30 key hospitals in China, where it is applied to the analysis of tumors and pathogens, serving over 550,000 patients in need of accurate diagnosis and treatment.
“Based on MGI’s DNBSEQ technology, our solution has low amplification error rate and high data utilization rate, which are crucial for ultra-deep sequencing of low-concentration or low-quality oncology samples,” said Dr. Fang. “We leverage this for targeting and immunotherapy guidance in advanced patients and drug sensitivity prediction and cancer minimum residual disease monitoring.”
The development of precision oncology has transformed how we approach the cancer care continuum – from prevention to detection, to diagnosis and treatment – for patients who are not only looking to survive but also to do so with an optimal quality of life. Supported by MGI, both CMTA® by ALACRIS and the GenePlus NGS total solution are laying the foundation for precise cancer control and ensuring all patients can enjoy effective, reliable, and affordable care for improved outcomes.
About MGI
MGI Tech Co. Ltd. (or its subsidiaries, together referred to MGI), headquartered in Shenzhen, is committed to building core tools and technology to lead life science through intelligent innovation. Based on its proprietary technology, MGI focuses on research & development, production and sales of sequencing instruments, reagents, and related products to support life science research, agriculture, precision medicine and healthcare. MGI is a leading producer of clinical high-throughput gene sequencers, and its multi-omics platforms include genetic sequencing, medical imaging, and laboratory automation. MGI’s mission is to develop and promote advanced life science tools for future healthcare. For more information, please visit the MGI website or connect with us on Twitter, LinkedIn or YouTube.
- For Research Use Only. Not for use in diagnostic procedures.
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STOCKHOLM, April 5, 2024 /PRNewswire/ — EQT AB’s Q1 Announcement 2024 will be published on Thursday 18 April 2024 at approximately 07:30 CEST. EQT will host a conference call at 08:30 CEST to present the report, followed by a Q&A session.
The presentation and a video link for the webcast will be available here from the time of the publication of the Q1 Announcement.
To participate by phone and ask questions during the Q&A, please register here in advance. Upon registration, you will receive your personal dial-in details.
The webcast can be followed live here and a recording will be available afterwards.
Information on EQT AB’s financial reporting
The EQT AB Group has a long-term business model founded on a promise to its fund investors to invest capital, drive value creation and create consistent attractive returns over a 5 to 10-year horizon. The Group’s financial model is primarily affected by the size of its fee-generating assets under management, the performance of the EQT funds and its ability to recruit and retain top talent.
The Group operates in a market driven by long-term trends and thus believes quarterly financial statements are less relevant for investors. However, in order to provide the market with relevant and suitable information about the Group’s development, EQT publishes quarterly announcements with key operating numbers that are relevant for the business performance (taking Nasdaq’s guidance note for preparing interim management statements into consideration). In addition, a half-year report and a year-end report including financial statements and further information relevant for investors is published. Finally, EQT also publishes an annual report including sustainability reporting.
Contact
Olof Svensson, Head of Shareholder Relations, +46 72 989 09 15
EQT Shareholder Relations, [email protected]
Rickard Buch, Head of Corporate Communications, +46 72 989 09 11
EQT Press Office, [email protected], +46 8 506 55 334
This information was brought to you by Cision http://news.cision.com
https://news.cision.com/eqt/r/invitation-to-presentation-of-eqt-ab-s-q1-announcement-2024,c3956826
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- Kia drives forward transformation into ‘Sustainable Mobility Solutions Provider’
- Roadmap enables Kia to proactively respond to uncertainties in mobility industry landscape, including changes in EV market
- Company to expand EV line-up with more models; enhance HEV line-up to manage fluctuation in EV demand
- Goal to sell 1.6 million EVs annually in 2030, introducing 15 models
- PBV to play a key role in Kia’s growth, targeting 250,000 PBV sales annually by 2030 with PV5 and PV7 models
- Kia to invest KRW 38 trillion by 2028, including KRW 15 trillion for future business
- 2024 business guidance : KRW 101 tln in revenue with KRW 12 tln in operating profit; operating profit margin of 11.9% on sales of 3.2 million units globally
- CEO reaffirms Kia’s commitment to ESG management
SEOUL, South Korea, April 5, 2024 /PRNewswire/ — Kia Corporation (Kia) today shared an update on its future strategies and financial targets at its CEO Investor Day in Seoul, Korea.
Based on its innovative achievements in the years since the announcement of mid-to-long-term business initiatives, Kia is focusing on updating its 2030 strategy announced last year and further strengthening its business strategy in response to uncertainties across the global mobility industry landscape.
During the event, Kia updated its mid-to-long-term business strategy with a focus on electrification, and its PBV business. Kia reiterated its 2030 annual sales target of 4.3 million units, including 1.6 million units of electric vehicles (EVs). The 2030 4.3 million annual sales target is 34.4 percent higher than the brand’s 2024 annual goal of 3.2 million units.
The company also plans to become a leading EV brand by selling a higher percentage of electrified models among its total sales, including hybrid electric vehicles (HEV), plug-in hybrid (PHEV), and battery EVs, projecting electrified model sales of 2.48 million units annually or 58 percent of Kia’s total sales in 2030.
“Following our successful brand relaunch in 2021, Kia is enhancing its global business strategy to further the establishment of an innovative EV line-up and accelerate the company’s transition to a sustainable mobility solutions provider,” said Ho Sung Song, President and CEO of Kia. “By responding effectively to changes in the mobility market and efficiently implementing mid-to-long-term strategies, Kia is strengthening its brand commitment to the wellbeing of customers, communities, the global society, and the environment.”
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VANCOUVER, BC, April 4, 2024 /PRNewswire/ — BioVaxys Technology Corp. (CSE: BIOV) (FRA: 5LB) (OTCQB: BVAXF) (the “Company“) is providing this bi-weekly update on the status of the management cease trade order granted on February 29, 2024 (the “MCTO“), by its principal regulator, the Ontario Securities Commission (the “OSC“), under National Policy 12-203 – Management Cease Trade Orders (“NP 12-203“), following the Company’s announcement on February 21, 2024 (the “Default Announcement“), that it was unable to file its audited annual financial statements for the year ended October 31, 2023, its management’s discussion and analysis of financial statements for the year ended October 31, 2023, its annual information form for the year ended October 31, 2023, and related filings (collectively, the “Required Annual Filings“). Under National Instrument 51-102, the Required Annual Filings were required to be made no later than February 28, 2024.
As a result of the delay in filing the Required Annual Filings, the Company was unable to file its interim financial statements for the three months ended January 31, 2024, its management’s discussion and analysis of financial statements for the three months ended January 31, 2024, and related filings (collectively, the “Required Interim Filings“). Under National Instrument 51-102, the Required Interim Filings were required to be made no later than April 1, 2024.
The Company anticipates filing the Required Annual Filings by April 30, 2024. The auditor of the Company requires additional time to complete its audit of the Company, including the Company’s recent acquisition of all intellectual property, immunotherapeutics platform technologies, and clinical stage assets of the former IMV Inc. that closed on February 16, 2024. In addition, the Company anticipates filing the Required Interim Filings immediately after the filing of the Required Annual Filings.
Except as herein disclosed, there are no material changes to the information contained in the Default Announcement. In addition, (i) the Company is satisfying and confirms that it intends to continue to satisfy the provisions of the alternative information guidelines under NP 12-203 and issue bi-weekly default status reports for so long as the delay in filing the Required Annual Filings and/or Required Interim Filings is continuing, each of which will be issued in the form of a press release; (ii) the Company does not have any information at this time regarding any anticipated specified default subsequent to the default in filing the Required Annual Filings and Required Interim Filings; (iii) the Company is not subject to any insolvency proceedings; and (iv) there is no material information concerning the affairs of the Company that has not been generally disclosed.
About BioVaxys Technology Corp.
BioVaxys Technology Corp. (www.biovaxys.com), a biopharmaceuticals company registered in British Columbia, Canada, is a clinical-stage biopharmaceutical company dedicated to improving patient lives with novel immunotherapies based on the DPX™ immune-educating technology platform and it’s HapTenix© ‘neoantigen’ tumor cell construct platform, for treating cancers, infectious disease, antigen desensitization, and other immunological fields. The Company’s clinical stage pipeline includes maveropepimut-S which is in Phase II clinical development for advanced Relapsed-Refractory Diffuse Large B Cell Lymphoma (DLBCL) and platinum resistant ovarian cancer, and BVX-0918, a personalized immunotherapeutic vaccine using it proprietary HapTenix© ‘neoantigen’ tumor cell construct platform which is soon to enter Phase I in Spain for treating refractive late-stage ovarian cancer. The Company is also capitalizing on its tumor immunology know-how and creation of a unique library of T-lymphocytes & other datasets post-vaccination with its personalized immunotherapeutic vaccines to utilize predictive algorithms and other technologies to identify new targetable tumor antigens. BioVaxys common shares are listed on the CSE under the stock symbol “BIOV” and trade on the Frankfurt Bourse (FRA: 5LB) and in the US (OTCQB: BVAXF). For more information, visit www.biovaxys.com and connect with us on X and LinkedIn.
ON BEHALF OF THE BOARD
Signed “James Passin“
James Passin, Chief Executive Officer
Phone: +1 646 452 7054
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