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Alys Pharmaceuticals launches with $100M financing from Medicxi to advance Immuno-Dermatology focused pipeline

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  • Co-founded by world leading dermatology experts and Medicxi
  • Merger of six asset-centric companies to form a new R&D-centric multi-platform pipeline in immuno-dermatology to harness cutting edge-science and technologies
  • Vision to transform the treatment paradigm for several dermatology indications of significant prevalence and major unmet need

BOSTON and GENEVA, Switzerland, Feb. 12, 2024 /PRNewswire/ — Alys Pharmaceuticals, Inc. (“Alys”), an immuno-dermatology focused company, launches today with an R&D pipeline enabled by multiple platform technologies and a $100 million financing by Medicxi. Originating from the aggregation of six asset-centric Medicxi companies, Alys boasts a robust pipeline of innovative programs and platforms targeting multiple dermatological indications.

Co-founded by Medicxi and several world leading dermatology and scientific experts, including John Harris (UMass Chan Medical School), Brian Kim (Icahn School of Medicine at Mount Sinai), Lars French (LMU, Munich), Nobel Prize winner Craig Mello (UMass Chan Medical School), Eric Deutsch (Gustave Roussy) and Mark Prausnitz (Georgia Institute of Technology), Alys aspires to redefine the landscape of dermatological treatments. The Company is run by co-founder and COO Thibaud Portal (formerly Galderma’s Global Head of Prescription Medicines) and Medicxi’s Francesco De Rubertis serves as Chairman of the Board.

Alys believes that emerging indications such as atopic dermatitis, vitiligo, alopecia areata and chronic spontaneous urticaria, will see the next breakthroughs in dermatological advancements. The pipeline also includes programs focused on underserved indications such as mastocytosis, cutaneous T-cell lymphoma or prevention of skin side effects of oncology therapies.

Alys is working with leading institutions such as Institut Gustave Roussy, UMass Chan Medical School, Icahn School of Medicine at Mount Sinai, Georgia Institute of Technology and Empa, the Swiss Federal Laboratories for Materials Science & Technology, demonstrating its commitment to collaborative research and development.

Alys combines the assets and platforms of Aldena Therapeutics, Graegis Pharmaceuticals, Granular Therapeutics, Klirna Biotech, Nira Biosciences and Vimela Therapeutics. With more than a dozen active programs, Alys anticipates further organic pipeline growth from its cutting-edge platforms, covering inflammatory diseases, autoimmune diseases, dermatology supportive care for cancer patients and rare dermatoses. Over the next three years, the company aims to deliver between seven to ten clinical Proof-of-Concept (POC) readouts, and potentially at least one program to advance to registrational studies.

Francesco De Rubertis, Chairman of Alys Pharmaceuticals and Partner at Medicxi commented: “We believe that bringing together several asset-centric companies with a phenomenal team will power up Alys to transform innovation in immuno-dermatology. Alys manages a broad pipeline of assets with diverse risk profiles and will hugely benefit from this change of scale and facilitated access to capital.”

Professor John Harris, Chief Innovation Officer of Alys Pharmaceuticals and Chair of Dermatology at UMass Chan Medical School, added: “It is uniquely exciting to oversee such a rich and diverse pipeline, bringing forward modalities that will break new ground in dermatology, including peptides, sophisticated antibodies, or vectorized siRNA.”

Professor Brian Kim, Vice Chair of Research in the Department of Dermatology at the Icahn School of Medicine at Mount Sinai, added: “With its diverse pipeline, Alys’ commitment to advancing the frontiers of immuno-dermatology has the potential to bring transformative solutions to patients worldwide.”

About Alys Pharmaceuticals

Alys Pharmaceuticals, Inc. (“Alys”) is a Boston and Geneva-based cutting edge pure-play immuno-dermatology company. Alys is backed by international investment firm Medicxi with $100M financing. Alys has a world class leadership team that brings together experts across dermatology and advanced scientific fields, including co-founders Craig Mello (UMass Chan Medical School), John Harris (UMass Chan Medical School), Brian Kim (Icahn School of Medicine at Mount Sinai), Lars French (LMU, Munich), Eric Deutsch (Gustave Roussy) and Mark Prausnitz (Georgia Institute of Technology). Alys is led by dermatology specialist, co-founder and COO Thibaud Portal

It was formed from the aggregation of 6 asset-centric Medicxi companies – Aldena Therapeutics, Graegis Pharmaceuticals, Granular Therapeutics, Klirna Biotech, Nira Biosciences and Vimela Therapeutics. Its pipeline boasts 14 active programs, targeting multiple dermatological indications, including atopic dermatitis, vitiligo, psoriasis and mastocytosis. For further information, please visit www.alyspharma.com.  

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About Medicxi

Medicxi is a healthcare-focused investment firm with the mission to create and invest in companies across the full drug development continuum. Leveraging deep expertise in drug development and company creation spanning over two decades, Medicxi invests in early and late-stage therapeutics with a product vision that can fulfill a clear unmet medical need. For more information, please visit: www.medicxi.com.

COI Statement

Mount Sinai and Brian Kim, UMass Chan Medical School, Craig Mello and John Harris, Georgia Institute of Technology and Mark Prausnitz, Gustave Roussy and Eric Deutsch, Lars French have financial interests in Alys.

 

View original content:https://www.prnewswire.co.uk/news-releases/alys-pharmaceuticals-launches-with-100m-financing-from-medicxi-to-advance-immuno-dermatology-focused-pipeline-302059125.html

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Ethara: EMIRATI SISTERS AMNA AND HAMDA AL QUBAISI RETURN TO YAS MARINA CIRCUIT FOR F1 ACADEMY SEASON FINALE

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The single-seater all-female championship series, Formula 1 Academy, wraps up an exciting season of racing at Yas Marina Circuit, supporting the Formula 1 season finale from 5-8 December

Ambassadors of Abu-Dhabi based team, Yas Heat Racing, Hamda and Amna will race at home with Red Bull Racing and Visa Cash App RB – capping off their second season in the championship

Link to Press Kit here

ABU DHABI, UAE, Dec. 6, 2024 /PRNewswire/ — In their second season competing in F1 Academy, the prestigious single-seater support series, Hamda and Amna Al Qubaisi have taken their racing careers to new heights. From 6-8 December, the two young Emirati drivers return to Yas Marina Circuit, where they first developed and honed their skills, to conclude an exhilarating season of on-track action.

 

 

Having cultivated their passion for racing in Abu Dhabi, the sisters flourished into competitive athletes under the Yas Heat Academy umbrella, the capital’s premier racing development programme. Now competing for two of the championship’s most competitive teams and serving as ambassadors for Yas Heat Racing, Amna and Hamda Al Qubaisi continue to embody the nation’s vision of nurturing young talent at the grassroots level.

Hamda Al Qubaisi was signed by Red Bull Racing for the team’s debut season in F1 Academy. The 22-year-old has delivered standout performances throughout the campaign, culminating in a strong showing at the penultimate race of the 2024 season in Doha last weekend going into the last round in 6th place.

Meanwhile, Amna Al Qubaisi is driving for Visa Cash App Racing in the championship. The 24-year-old Emirati trailblazer has impressed fans and competitors alike, consistently showcasing her skill and determination on the track.

Looking ahead to their return to Yas Marina Circuit, Amna Al Qubaisi shared her excitement:
“I’ve been racing for 10 years now, I started in karting here at Yas Marina circuit, and I slowly developed from karting nationally, moving up to juniors, then seniors, and the next step was Formula 4. Being a Yas Heat ambassador has been great. Yas Heat has helped me develop my skills. They have taught me, coached me, provided me with the the appropriate insights. It is a program that is going to help young racers in karting move up the ladder.”

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Red Bull Racing driver Hamda Al Qubaisi added: “Racing at Yas Marina Circuit is both nostalgic and empowering for us as Emirati women. Representing the UAE and Yas Heat Racing on a global stage has been an incredible opportunity, and we look forward to finishing the season on a high note by giving all we can for our teams, surrounded by friends and family.”

Formula 1 Academy joins a packed racing programme at Yas Marina Circuit during the 2024 Abu Dhabi Grand Prix weekend, which also features the FIA Formula 2 season finale and the FIA Formula 4 Middle East Trophy Round. Offering non-stop entertainment, the Abu Dhabi GP weekend kicks off on Thursday, 4 December, promising an unforgettable four-day celebration on Yas Island.

For more information, please visit: https://www.yasmarinacircuit.com/en/motorsports/yas-heat-racing

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Photo: https://mma.prnewswire.com/media/2575429/Ethara_Hamda_Qubaisi.jpg

 

Hamda Qubaisi

 

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The Hashgraph Association Pledges $1.5M to Global Centre for Sustainable Digital Finance

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ZUG, Switzerland, Dec. 6, 2024 /PRNewswire/ — The Hashgraph Association (THA), a Swiss innovation leader at the forefront of empowering a digital future for all, has committed $1.5 million to the Global Centre for Sustainable Digital Finance as a founding member. This collaboration aims to drive and fund groundbreaking research and innovation at the intersection of sustainability and digital finance.

The Global Centre for Sustainable Digital Finance, which brings together academic experts from Stanford University, the University of Zurich (UZH), and the Korea Advanced Institute of Science & Technology (KAIST) in South Korea, focuses on developing and accelerating research in sustainable digital finance with impact and training students and practitioners to foster innovation on a global scale. With THA’s committed funding, the Centre will expand its efforts to address global challenges in banking, ESG, financial inclusion, and climate finance.

The Hashgraph Association’s involvement extends beyond just funding. The organization will collaborate with the Centre to conceptualize and implement projects leveraging its cutting-edge Hedera DLT platform. Additionally, THA will equip 360 students annually with skills in mastering DLT using the Hedera Hashgraph platform, with over 2,160 students to be trained over the duration of the partnership, which is 6 years. It will also train 10 trainers equivalent to 60 trainers over this period. Participants will receive Hedera certifications in the form of NFTs (Non-Fungible Tokens), adding a digital-first dimension to credentialing.

Kamal Youssefi, President of The Hashgraph Association, stated, “At The Hashgraph Association, we are proud to continue supporting organizations that deliver environmentally sustainable finance solutions in an innovative and compliant way. A recent environmental impact study by University College London (UCL) comparing different distributed ledger networks proved that Hedera is the world’s most sustainable network. The Global Center for Sustainable Digital Finance fits perfectly into our Hedera Enablement Program, furthering THA’s efforts to expand research and development in Web3 and support sustainable initiatives.”

A recent survey of 37 UNDP country offices revealed that sustainable digital finance is a priority for many nations, yet only 40% have a digital finance strategy. THA’s partnership with the Global Centre for Sustainable Digital Finance aims to fill this gap by bridging digital finance and sustainability through innovative, education, impactful research and implementation.

Thomas Puschmann, Founder and Executive Director of Global Center for Sustainable Digital Finance, states, “We are very pleased to be working with The Hashgraph Association. Sustainable digital finance has the potential to build inclusive, safe digital foundations, and technologies such as DLT, AI, and IoT, helping to increase transparency and reliability of information, especially in the climate financing domain. These foundations also aid in tackling corruption issues when funding SDG (Sustainable Development Goals) projects.”

The Hashgraph Association launched a $50 million Sustainability Venture Studio for enterprises earlier this year and has also partnered with Deloitte to enhance the verification of corporate ESG impact, reporting, and sustainability claims, leveraging the Hedera Guardian as the trusted balance sheet of the earth. Collaborating with Deloitte NL Risk Advisory B.V. in the Netherlands, this partnership focuses on enabling corporations to measure, track, report, and tokenize evidence-based ESG impact and sustainability claims on Hedera and ensuring a carbon-neutral future.

Kamal Youssefi, President of The Hashgraph Association is available for an interview upon request

About Global Center for Sustainable Finance 
The financial system is currently being transformed by digitization and sustainability. However, existing knowledge on the topic of Sustainable Digital Finance, which bridges both areas, is still rare and a more comprehensive understanding of the domain is a missing component. The Global Center for Sustainable Digital Finance focuses on this domain and aims to develop innovative approaches (research), accelerate those approaches (impact), and train students and practitioners to foster innovation on a global scale (education).

About The Hashgraph Association
The Hashgraph Association is at the forefront of the digital enablement and empowerment of organizations through the broad adoption of Hedera-powered enterprise-grade solutions and decentralized applications, which includes supporting and funding of training, innovation, and venture-building programs globally. As a non-profit organization headquartered in Switzerland, The Hashgraph Association provides funding for innovation, research, and development that enables economic inclusion and a digital future for all, with a positive environmental, social, and governance (ESG) impact.

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For Media Enquiries:
Dustin Rotenberg, Chief Marketing Officer
[email protected]

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Thomson Reuters named a Leader in 2024 IDC MarketScape for Worldwide SaaS and Cloud-enabled Sales and Use Tax Automation Software for Enterprise

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TORONTO, Dec. 6, 2024 /PRNewswire/ — Thomson Reuters (NYSE/TSX: TRI), a global content and technology company, today announced that it has been positioned as a Leader in two IDC MarketScape reports – IDC MarketScape: Worldwide SaaS and Cloud-Enabled SaaS Sales and Use Tax Automation Software for Enterprise 2024 Vendor Assessment (doc #US52035324, December 2024), and IDC MarketScape: Worldwide Value-Added Tax Management Applications 2024 Vendor Assessment (doc #US52732824, December 2024).

“In today’s rapidly evolving global marketplace, tax compliance has become increasingly complex for multinational corporations. At Thomson Reuters, we’re committed to empowering our customers with cutting-edge technology that not only ensures compliance but also enhances their competitive edge,” said Ray Grove, head of Corporate Tax and Trade at Thomson Reuters.

“We believe our recognition as a Leader in both the enterprise SUT and VAT markets in this IDC MarketScape underscores our unwavering dedication to our customers’ success. Through our trusted ONESOURCE solutions, serving over 205 countries and territories, we continue to push the boundaries of innovation. Our vision is to create a seamlessly connected suite of global indirect tax calculation, reporting, and e-invoicing capabilities, providing best-in-class technology to enable our customers to navigate the complexities of tax compliance with confidence and agility.”

“Businesses of all sizes are grappling with an increasingly complex tax landscape, and they are turning to technology vendors for sophisticated tax automation solutions that seamlessly integrate, ensure compliance, and boost operational efficiency,” said Kevin Permenter, research manager at IDC. “Thomson Reuters has consistently demonstrated its commitment to innovation and customer success in the SaaS and cloud-enabled Value-Added Tax automation software market. Their ONESOURCE platform stands out for its comprehensive global coverage, robust integration capabilities, and advanced features powered by edge computing and AI. They are positioned well to address the evolving needs of businesses facing intricate tax compliance challenges across multiple jurisdictions.”

Pagero, part of Thomson Reuters, was also recently named a Leader in the IDC MarketScape: European Compliant e-Invoicing 2024 Vendor Assessment (doc #EUR151806424, September 2024). As a key part of Thomson Reuters e-invoicing offering, ONESOURCE Pagero supports businesses to accelerate growth with trusted, automated e-invoicing software that streamlines global compliance processes to unlock valuable business insights.

Thomson Reuters ONESOURCE offers comprehensive tax compliance solutions, including automated tax return preparation and filing for Sales and Use Tax and VAT. It integrates with major ERPs and provides tax determination and calculation for all transactions. ONESOURCE also features edge computing for faster, more controlled tax calculations. Recently, Thomson Reuters launched ONESOURCE with CoCounsel globally, integrating generative AI assistance. This enhanced solution combines a new AI Product Support skill with CoCounsel, Thomson Reuters professional-grade generative AI assistant that provides instant, natural-language answers drawn from Thomson Reuters trusted, proprietary content.

About IDC MarketScape

IDC MarketScape vendor assessment model is designed to provide an overview of the competitive fitness of technology and service suppliers in a given market. The research utilizes a rigorous scoring methodology based on both qualitative and quantitative criteria that results in a single graphical illustration of each supplier’s position within a given market. IDC MarketScape provides a clear framework in which the product and service offerings, capabilities and strategies, and current and future market success factors of technology suppliers can be meaningfully compared. The framework also provides technology buyers with a 360-degree assessment of the strengths and weaknesses of current and prospective suppliers.

Thomson Reuters

Thomson Reuters (NYSE / TSX: TRI) (“TR”) informs the way forward by bringing together the trusted content and technology that people and organizations need to make the right decisions. The company serves professionals across legal, tax, accounting, compliance, government, and media. Its products combine highly specialized software and insights to empower professionals with the data, intelligence, and solutions needed to make informed decisions, and to help institutions in their pursuit of justice, truth, and transparency. Reuters, part of Thomson Reuters, is a world leading provider of trusted journalism and news. For more information, visit tr.com.

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Media contact 
Kirsty Bennett  
Director, Customer and Product PR  
[email protected]

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