USA News Group Commentary Issued on behalf of Oncolytics Biotech Inc.

VANCOUVER, BC, May 15, 2024 /PRNewswire/ — USA News Group – Hope is rising in the fight against one of the deadliest cancers in the world, as a new study recently claimed that a blood test can accurately detect early-stage pancreatic cancer with 97% accuracy. According to Johns Hopkins Medicine, up to 10% of patients who receive an early diagnosis become disease-free after treatment, meaning the earlier it’s detected, the better the patient’s chances to survive. The American Cancer Society estimates that about 66,440 people (34,530 men and 31,910 women) will be diagnosed with pancreatic cancer in the USA this year, projecting about 51,750 people will succumb to the disease. Working diligently behind the scenes, several biotech drug developers are making progress in new treatments, including recent updates from Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Candel Therapeutics, Inc. (NASDAQ: CADL), ABVC BioPharma, Inc. (NASDAQ: ABVC), CytomX Therapeutics, Inc. (NASDAQ: CTMX), and Amgen Inc. (NASDAQ: AMGN).

Pelareorep, an intravenously delivered immunotherapeutic agent being developed by Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), is gaining momentum as a potential treatment for multiple cancers, especially breast cancer and pancreatic cancer. In late 2022, the FDA granted pelareorep Fast Track Designation for treating pancreatic cancer, following promising clinical results. Now Oncolytics has recently announced a preliminary collaboration with the Global Coalition for Adaptive Research (GCAR), with the purpose of commencing planning activities for the evaluation of pelareorep in the treatment of first-line metastatic pancreatic ductal adenocarcinoma (PDAC), as part of GCAR’s anticipated master protocol for metastatic pancreatic cancer.

GCAR’s activities are already underway to finalize the seamless Phase 2/3 master protocol design that will evaluate multiple investigational therapies for pancreatic cancer treatment. Thus, the intent of the pelareorep study will be to produce registration-enabling data.

“We are thrilled to collaborate with GCAR and are honored that pelareorep has been selected as the first therapeutic for evaluation in GCAR’s planned adaptive trial in pancreatic cancer patients,” said Dr. Matt Coffey, President and Chief Executive Officer of Oncolytics. “We believe this opportunity presents a strategic and efficient pathway forward for the development of pelareorep to address an urgent need for pancreatic cancer patients. GCAR’s anticipated trial design seeks to cut registrational study time and reduce trial costs, speeding up the journey to potentially deliver effective cancer treatment sooner.”

Oncolytics is also now advancing its lead asset further, having recently received regulatory clearance to evaluate pelareorep in combination with modified FOLFIRINOX +/- Tecentriq (from Roche) in pancreatic cancer in a new cohort from its ongoing GOBLET study, following German regulatory and ethics approvals. The new cohort is bolstered by a US$5 million Therapeutic Accelerator Award from the Pancreatic Cancer Action Network (PanCAN), an inventive initiative aimed at rapidly advancing the development of new treatments for pancreatic cancer.

Achieving these positive results from the pelareorep/mFOLFIRINOX combination could greatly elevate Oncolytics’ prospects in tackling pancreatic cancer. Oncolytics has previously reported encouraging data from pelareorep paired with gemcitabine and nab-paclitaxel. The Oncolytics team believes that if the mFOLFIRINOX combination demonstrates improvements in response rate over historical control trials, this treatment approach could move forward to a registration-enabling study, offering two potential pelareorep-based therapies for pancreatic cancer patients. Additionally, planned translational research studies for this cohort will further explore the understanding of pelareorep’s mechanism of action, including its impact on the tumor microenvironment (TME).

As a part of this evaluation, Oncolytics will examine the relationship between tumor responses and the expansion of tumor-infiltrating lymphocytes (TILs) in the blood, an effect noted in previous pancreatic cancer studies. The company plans to start enrolling patients into the mFOLFIRINOX/pelareorep study cohort in Q2 2024.

For Candel Therapeutics, Inc. (NASDAQ: CADL), the FDA granted Orphan Drug Designation to their leading multimodal biological candidate, CAN-2409, for pancreatic cancer treatment. This recognition came shortly after Candel shared updated overall survival data from its ongoing randomized phase 2 clinical trial of CAN-2409 combined with valacyclovir (prodrug) and standard-of-care chemoradiation, followed by surgery for borderline resectable pancreatic ductal adenocarcinoma (PDAC).

“We recently reported data from the phase 2 randomized clinical trial of CAN-2409 in borderline resectable pancreatic cancer, showing that CAN-2409, when added to standard of care, more than doubled the median overall survival obtained with standard of care alone,” said Paul Peter Tak, MD, PhD, FMedSci, President and CEO of Candel. “We are pleased that the FDA has now granted Candel with both Orphan Drug and Fast Track Designation to this program, as we seek to reshape the treatment paradigm in pancreatic cancer.”

Clinical-stage biopharmaceutical company ABVC BioPharma, Inc. (NASDAQ: ABVC) recently announced it has entered into a definitive agreement with private company OncoX BioPharma, Inc. in its fight against pancreatic cancer. Through its affiliate Rgene Corporation, ABVC and OncoX are set to collaborate on combination therapy the duo believes will help treat pancreatic cancer and improve patient outcomes significantly, with ABVC and Rgene set to receive an aggregate license fee of $12.5 million in cash or shares from OncoX within the next 30 days.

“We are excited to announce this collaboration with OncoX, which represents a significant step forward in our commitment to developing transformative treatments for pancreatic cancer,” said Dr. Uttam Patil, CEO of ABVC. “By combining our strengths, we can make meaningful progress in addressing this devastating disease. The collaboration will draw on ABVC’s portfolio of combination therapies pipeline, which has shown promise in preclinical and early clinical studies.”

Among ABVC’s portfolio is its ABV-1703 (IND 136309) for pancreatic cancer therapy. As part of an Investigational New Drug (IND) application for ABV-1703 is the proposal for the clinical investigation of BLEX 404 as a combination therapy drug with chemotherapy. BLEX 404 is made with the active ingredient glucan, which is extracted from Grifola frondose (maitake mushrooms), an edible fungus with high medical and commercial value in Asia.

“This partnership exemplifies our dedication to advancing the field of oncology and bringing hope to patients facing pancreatic cancer,” said Wen-Pin Yen, CEO of OncoX. “Together with ABVC, we are committed to pushing the boundaries of innovation to improve outcomes for patients in need. The two companies aim to deliver a novel treatment option for pancreatic cancer patients by combining their resources, expertise, and innovative approaches.”

Leading drug developer in the field of masked, conditionally activated biologic therapeutics, CytomX Therapeutics, Inc. (NASDAQ: CTMX), recently announced positive initial data from its ongoing CX-904 Phase 1a dose escalation clinical study with its global development partner, Amgen Inc. (NASDAQ: AMGN). CytomX and Amgen are collaborating on CX-904, a bispecific PROBODY candidate designed to engage T-cells by targeting the epidermal growth factor receptor (EGFR) on cancer cells and the CD3 receptor on T cells.

Within the clinical study results, CX-904 not only demonstrated a favorable safety profile with no cytokine release syndrome, but also presented encouraging initial signs of efficacy observed for CX-904 in advanced pancreatic cancer, including 2 of 6 patients (33%) with a confirmed partial response, and all 6 patients (100%) with disease control.

“We are delighted to share these initial results today for CX-904, a highly innovative masked T-cell engager that embodies our vision at CytomX of transforming lives with safer, more effective therapies,” said Sean McCarthy, D.Phil., CEO and Chairman of CytomX. “These data build on more than a decade of innovation at CytomX, and, we believe, open broad new possibilities for T-cell engagers across many targets and cancer types. We look forward to continuing to explore the potential of this exciting agent in multiple EGFR positive cancers and to determining longer term strategy with our global development partner, Amgen.”

Article Source: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/ 

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LONDON, May 15, 2024 /PRNewswire/ — The latest Bitcoin halving, which took place on April 19^th, 2024, has been the subject of intense discussions among crypto enthusiasts. The event reduced the reward for mining new blocks by half, not only affecting miners but also broader market dynamics. To this end, TheRevenueCenterPro is actively revamping its offerings to meet the anticipated changes in the market landscape following this significant landmark. The strategic updates are intended to assist clients in dealing with the new challenges and opportunities that are presented by Bitcoin halving.

“We prioritize our clients by offering a broad selection of tradable assets and the latest technologies, all designed to enhance the efficiency and effectiveness of their trading experiences,” stated Joshua Govender, TheRevenueCenterPro spokesperson, “After the recent Bitcoin Halving event, we have made some modifications in our offerings to reflect the new market dynamics. These improvements are exclusively curated to help the users leverage post-halving volatility and potential growth opportunities.”

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About TheRevenueCenterPro

TheRevenueCenterPro is globally recognized as an excellent trading brand, which offers a full set of trading features and essential tools. The broker functions as a bridge connecting the traders to diverse financial landscapes, allowing them to enjoy access to assets like forex pairs, commodities, indices, and cryptocurrencies. Moreover, the firm offers five different account types to fit the particular requirements and objectives of each user. In a nutshell, The Revenue Center Pro is not merely a trading platform; it is a comprehensive trading system that facilitates its members with all the necessary information, products, and instruments to achieve the best possible trading results.

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View original content:https://www.prnewswire.co.uk/news-releases/the-revenue-center-pro-rolls-out-updated-offerings-post-bitcoin-halving-302146531.html

• Surpassed Rs.89,600 Crores in revenues for FY’24
• Q4 FY’24 YoY Revenue growth of 3%; PAT growth of 5%
• FY’24 YoY Revenue growth of 13%

CHENNAI, India,/PRNewswire/ — Redington Ltd (NSE: REDINGTON), today announced its financial results for the quarter ended March 31, 2024 (Q4 FY’24) and full financial year FY’24 delivering strong performance vis-à-vis the industry across all business segments. 

At Rs. 22,513 Crores overall global revenues for Q4 have been the highest ever performance for Q4 of any year, with a 3% YoY growth and at Rs. 326 Crores, PAT grew at 5% YoY. For the full year FY24 the company reported a revenue of Rs. 89,610 Crores which is a growth of 13% YoY and a PAT of Rs. 1,219 Crores.

Supported by solid execution across businesses and geographies, Redington continues to gain share and secure new opportunities in the markets they compete in. In Q4, some of the Company’s key Geographies grew well, viz. India growing at 9% YoY and KSA (Kingdom of Saudi Arabia) growing at 15% YoY. The company emphasized that this record performance is an outcome of continued investments in improving our route to market capabilities, building deeper brand relationships, making breadth of offerings more comprehensive and innovations in business model.

“Building on the momentum from a strong Q3, Redington’s Q4 and FY24 results reflect the continued success of our efforts towards driving profitable growth. We’ve adapted with a  focus on profitable growth geographies, investing in new revenue streams, and enhancing our capabilities. This fiscal year stands out for achieving stable growth, across all business units, while continuing to maintain leadership position. While technology distribution remains our core strength, the growth of the cloud business has been enabled by faster adoption of subscription and consumption business, enhanced by professional services. With our strong engagement with the Brands through initiatives, business plans, differentiated go to market approaches, and the slew of AI enabled solutions being launched by the vendors that will be distributed by us, will position Redington for sustainable growth and market share leadership in the years ahead.” said Mr. V.S. Hariharan, Group CEO,  Redington Ltd. 

*The detailed Financial Report for FY23 can be accessed here: https://www.bseindia.com/xml-data/corpfiling/AttachLive/6491f885-b5cd-48de-91cd-ba69af88e664.pdf

Safe Harbor

Certain statements in this release are forward-looking statements. The business involves various risks, and uncertainties that could result in the actual results to differ materially from those indicated here. All forward looking statements made herein are based on information presently available to the management of the Company and the Company does not undertake to update any forward looking statement that may be made from time to time by or on behalf of the Company.

About Redington Ltd:
Redington Limited, an integrated technology solutions provider and a Fortune 500 company, enables businesses in their digital transformation journeys by addressing technology friction – the gap between innovation and adoption. With presence across 38 markets through 60 subsidiary offices, over 300+ brand associations, and 43,000 channel partners, Redington enables seamless and end-to-end distribution for all categories of IT/ITeS, Telecom, Lifestyle, and Solar products in India, Singapore, South Asia, Middle-East, Africa and Turkey.  Through its concentrated focus on technology, innovations, and partnerships, Redington is one of the most trusted distributors of products, services, and solutions across the world.

For more details, please visit https://redingtongroup.com/

Media Contact:
Himani Rautela 
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View original content:https://www.prnewswire.co.uk/news-releases/redington-reports-record-q4-revenue-of-rs-22-513-crore-annual-revenue-surges-to-rs-89-610crore-302146686.html