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Early Detection Breakthrough: Biotech Companies Lead the Way in Pancreatic Cancer Treatment

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USA News Group Commentary

Issued on behalf of Oncolytics Biotech Inc.

VANCOUVER, BC, May 17, 2024 /PRNewswire/ — USA News Group – A new study is bringing hope in the fight against one of the deadliest cancers, revealing a blood test that can detect early-stage pancreatic cancer with 97% accuracy. This breakthrough is crucial, as Johns Hopkins Medicine reports that up to 10% of patients diagnosed early can become disease-free after treatment. The American Cancer Society estimates that around 66,440 people (34,530 men and 31,910 women) in the USA will be diagnosed with pancreatic cancer this year, with approximately 51,750 expected to succumb to the disease. Behind the scenes, biotech drug developers are working diligently to advance new treatments and improve patient outcomes, including recent updates from Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), Roche Holding AG (OTCQX: RHHBY), Merus N.V. (NASDAQ: MRUS), MacroGenics, Inc. (NASDAQ: MGNX), and Immuneering Corporation (NASDAQ: IMRX).

One innovative immunotherapeutic agent, pelareorep, developed by Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC), is advancing as a potential treatment for multiple cancers, particularly breast and pancreatic cancer. After receiving Fast Track Designation from the FDA for pancreatic cancer in late 2022 due to encouraging clinical results, Oncolytics has embarked on a preliminary collaboration with the Global Coalition for Adaptive Research (GCAR). This partnership is set to begin planning the evaluation of pelareorep for first-line metastatic pancreatic ductal adenocarcinoma (PDAC) within GCAR’s anticipated master protocol, which is expected to generate registration-enabling data.

“We are thrilled to collaborate with GCAR and are honored that pelareorep has been selected as the first therapeutic for evaluation in GCAR’s planned adaptive trial in pancreatic cancer patients,” said Dr. Matt Coffey, President and Chief Executive Officer of Oncolytics. “We believe this opportunity presents a strategic and efficient pathway forward for the development of pelareorep to address an urgent need for pancreatic cancer patients. GCAR’s anticipated trial design seeks to cut registrational study time and reduce trial costs, speeding up the journey to potentially deliver effective cancer treatment sooner.”

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Oncolytics is progressing with its lead asset, having recently secured regulatory clearance to evaluate pelareorep in combination with modified FOLFIRINOX (mFOLFIRINOX) +/- Tecentriq® from Roche Holding AG (OTCQX: RHHBY) in newly diagnosed pancreatic cancer patients in a new cohort of its ongoing GOBLET study. This approval follows clearance from German regulatory and ethics bodies. The new cohort is supported by a US$5 million Therapeutic Accelerator Award from the Pancreatic Cancer Action Network (PanCAN), an innovative program designed to expedite the development of new treatments for pancreatic cancer.

Positive outcomes from the pelareorep/mFOLFIRINOX combination could significantly boost Oncolytics’ efforts in combating pancreatic cancer. Previously, Oncolytics has shared encouraging data results from the combination of pelareorep with Tecentriq, gemcitabine and nab-paclitaxel. The team at Oncolytics is optimistic that if the mFOLFIRINOX combination shows improved response rates compared to historical control trials, it could advance to a registration-enabling study. This would provide two potential pelareorep-based treatment options for pancreatic cancer patients. Additionally, planned translational research for this cohort will delve deeper into understanding pelareorep’s mechanism of action, particularly its effects on the tumor microenvironment (TME).

In this evaluation, Oncolytics will also explore how tumor responses correlate with the expansion of tumor-infiltrating lymphocytes (TILs) in the blood, an effect seen in prior pancreatic cancer studies. The company intends to commence patient enrollment for the mFOLFIRINOX/pelareorep study cohort in Q2 2024.

Roche recently had an investigator-led trial of Tecentriq terminated back in March, while another clinical supply agreement was reached in May to evaluate another Tecentriq combination. Roche is also moving forward with partners BioNTech for a jointly-developed pancreatic cancer vaccine that demonstrated lasting responses in an early trial. In Phase II trials, the mRNA vaccine is administered along with Roche’s Tecentriq and chemo against pancreatic cancer.

Now Roche is also working through an agreement with PathAI, a global leader in artificial intelligence AI-powered technology for pathology. Under the terms of the deal, PathAI will work exclusively with Roche Tissue Diagnostics (RTD) to develop AI-enabled digital pathology algorithms in the companion diagnostics space.

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“This collaboration with Roche is a testament to our shared commitment to advancing the field of digital pathology and AI-enabled diagnostics for both drug development and clinical care,” said Dr. Andy Beck, CEO and Co-Founder of PathAI. “High medical value diagnostic products with seamless integration into the laboratory workflow will accelerate the transition to digital pathology as the standard to aid clinicians in diagnosis and biomarker characterisation.”

Recently the FDA granted priority review to a biologics license application (BLA) from Merus N.V. (NASDAQ: MRUS), seeking the approval of zenocutuzumab (MCLA-128) (“Zeno”) for use in the treatment of patients with pancreatic cancer (and NSCLC). The FDA has already granted Breakthrough Therapy Designation (BTD) to Zeno for the treatment of patients with advanced unresectable or metastatic NRG1 fusion-positive pancreatic cancer following progression with prior systemic therapy or who have no satisfactory alternative treatment options.

FDA acceptance of our first BLA represents an important achievement for Merus and an important potential treatment opportunity for patients with NRG1-positive cancer, a disease with poor prognosis and high unmet need,” said Andrew Joe, MD, Chief Medical Officer at Merus NV. “Zenocutuzumab has the potential to be the first and only targeted therapy for patients with NRG1-positive lung and pancreatic cancer, and may offer a substantial improvement over currently available therapies.”

MacroGenics, Inc. (NASDAQ: MGNX) recently delivered an update on its corporate progress, which included preclinical data for its MGC028 at the recent AACR Annual Meeting, after the antibody-drug conjugate (ADC) demonstrated specific antitumor activity in in vivo models representing pancreatic cancer (among other cancers).

“In preclinical studies, MGC028 demonstrated specific antitumor activity in in-vivo models representing gastric, lung, pancreatic, colorectal, small cell carcinoma, the head and neck, and cholangiocarcinoma,” said Scott Koenig, President and CEO of MacroGenics during a recent earnings call. “In addition, in a nonhuman primate study, MGC028 was well tolerated at high dose levels with mild reversible side effects and no ocular toxicity, which is offered a concern with tubulin-inhibitor-based ADCs. These promising preclinical results support the continued investigation of MGC028 as a therapeutic option for treating ADAM9 solid tumors.”

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Back in February, Immuneering Corporation (NASDAQ: IMRX) was granted Fast Track Status for its IMM-1-104 for pancreatic cancer. IMM-1-104 is designed to provide universal-RAS activity through deep cyclic inhibition of the MAPK pathway with once-daily oral dosing.

“We welcome FDA’s decision to grant Fast Track designation for IMM-1-104,” said Ben Zeskind, Ph.D., Co-founder and CEO of Immuneering in a statement. “Our Phase 1/2a study is designed to evaluate IMM-1-104 in pancreatic cancer, as well as a number of other tumor types associated with the RAS pathway. We look forward to a data-rich 2024 as we plan to provide multiple readouts from our study this year.”

Article Source: https://usanewsgroup.com/2023/10/02/the-most-undervalued-oncolytics-company-on-the-nasdaq/ 

USA NEWS GROUP
[email protected]
(604) 265-2873

DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. (“MIQ”). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles.

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While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment.

View original content:https://www.prnewswire.co.uk/news-releases/early-detection-breakthrough-biotech-companies-lead-the-way-in-pancreatic-cancer-treatment-302149143.html

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InScope secures $4.3m to revolutionise financial reporting and auditing

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InScope, a newly launched FinTech company, has successfully raised $4.3 million to expand its innovative financial reporting and auditing platform.

According to PYMNTS, the funding round included significant contributions from prominent investors such as Lightspeed and Better Tomorrow Ventures.

InScope is focused on transforming the traditional processes of financial reporting and auditing for private companies. The company leverages advanced technologies, including generative AI and large language models, to automate and streamline the compilation of financial statements—tasks that have historically been prone to errors and required extensive manual effort.

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The new capital will be used to enhance InScope’s platform capabilities. The company aims to shift accountants’ focus from laborious manual tasks to more strategic initiatives, thereby empowering finance professionals with tools to complete reporting and auditing tasks quickly and efficiently.

InScope’s system compiles data from a company’s core systems, such as ERP, along with publicly available information, and transforms these inputs into GAAP-compliant financial and audit documents.

InScope CEO and co-founder Mary Antony stated, “Our technology dramatically reduces the time and effort required for financial reporting and auditing, eliminating the need for outdated manual processes.” Her co-founder and COO, Kelsey Gootnick, also emphasized the transformative potential of InScope, which they conceived out of their own frustrations with existing financial processes.

The company has already begun collaborating with a select group of companies to refine and enhance their financial reporting capabilities. JC Bahr-de Stefano, a venture capital investor at Better Tomorrow Ventures, commented on this partnership: “InScope is already working with a handful of companies to help streamline their financial reporting needs and enable accountants to complete their reporting tasks in minutes instead of months.”

Source: fintech.global

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Citi extends USD Clearing service to Middle East in partnership with Emirates NBD

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Citi has partnered with Dubai-based banking group Emirates NBD to launch its USD Clearing service in the Middle East.

Through this collaboration, Emirates NBD will offer the USD Clearing service, along with its commercial and treasury payment execution capabilities, to corporate and retail clients via its branch networks in the UAE and Saudi Arabia. This service will enable clients to make cross-border USD payments with continuous availability, addressing current payment flow challenges posed by varying transaction cut-off times in the UAE.

“The introduction of 24/7 USD Clearing will support the growth ambitions of our clients by giving them the ability to seamlessly transfer funds in a timely manner without having to worry about cutoffs and holidays,” said Ahmed Al Qassim, group head of wholesale banking at Emirates NBD.

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Following the initial launch, the service will be extended to all Emirates NBD branches in the Middle East and globally, including partnerships with third-party institutions.

According to its website, Emirates NBD currently operates 853 branches in the UAE, Egypt, India, Turkey, Saudi Arabia, Singapore, the UK, Austria, Germany, Russia, and Bahrain.

Shahmir Khaliq, Citi’s head of services, described the collaboration as “an important step in our journey to creating a multibank solution that is designed to deliver an end-to-end, ‘always on’ experience for participant banks and their customers.”

“Our 24/7 USD Clearing service is a clear differentiator in the market,” Khaliq continued. “It demonstrates the full value of our globally leading cross-border payments and clearing capabilities, which enable our clients to make payments faster and in a more efficient and transparent manner.”

Source: fintechfutures.com

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New partnership between BIS and MAS targets climate risks in finance

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The Bank for International Settlements (BIS) and the Monetary Authority of Singapore (MAS) have recently collaborated on an innovative initiative.

The BIS, an institution dedicated to fostering international monetary and financial cooperation, and the MAS, Singapore’s central bank responsible for monetary policy, financial regulation, and supervision, have teamed up to tackle a pressing global challenge.

Their partnership aims to develop a blueprint for a climate risk platform designed to integrate regulatory and climate data. This platform will enable financial authorities worldwide to better identify, monitor, and manage climate-related risks within the financial system.

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The BIS, through its Innovation Hub Centre in Singapore, is addressing financial stability concerns posed by climate change. The MAS adds its regulatory expertise and focus on sustainable finance to the effort. Both institutions recognize the complex challenges posed by climate change, including significant data gaps and the difficulty of assessing associated risks.

Project Viridis, led by the BIS Innovation Hub, outlines the essential features and metrics of the proposed climate risk platform. This platform is designed to provide comprehensive data on financed emissions, exposure to physical risks, and forward-looking assessments under various climate scenarios. As the impact of climate change on global financial markets escalates, adaptive and innovative responses are necessary.

The partnership also leverages advanced technologies such as natural language processing to extract and analyze climate-related data from corporate disclosures. This enables a deeper understanding of financial institutions’ climate-related risks and identifies potential areas requiring more intensive risk assessment.

Maha El Dimachki, head of the BIS Innovation Hub Singapore Centre, stated, “Project Viridis demonstrates how regulatory data can be integrated with climate data, extracted from corporate disclosure documents using natural language processing techniques. This provides authorities with insights into climate-related financial risks, helping them form an initial view of financial institutions’ risk exposures and identify areas that may require deeper risk assessment.”

Source: fintech.global

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